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10.1021/nl503220s http://scihub22266oqcxt.onion/10.1021/nl503220s C4264854!4264854 !25379951     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25379951 &cmd=llinks): Failed to open stream: HTTP request failed! 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Highly specific plasmonic biosensors for ultrasensitive microRNA detection in plasma from pancreatic cancer patients |pdf=|usr=}}{{25379951 }} gab.com Text Highly specific plasmonic biosensors for ultrasensitive microRNA detection in plasma from pancreatic cancer patients JO: Nano Lett http://www.kidney.de/pget.php?&tw=1&pmid=25379951 #FOAvip MicroRNAs (miRs) are small noncoding RNAs that regulate mRNA stability and/or translation. Because of their release into the circulation and their remarkable stability, miR levels in plasma and other biological fluids can serve as diagnostic and prognostic disease biomarkers. However, quantifying miRs in the circulation is challenging due to issues with sensitivity and specificity. This Letter describes for the first time the design and characterization of a regenerative, solid-state localized surface plasmon resonance (LSPR) sensor based on highly sensitive nanostructures (gold nanoprisms) that obviates the need for labels or amplification of the miRs. Our direct hybridization approach has enabled the detection of subfemtomolar concentration of miR-X (X = 21 and 10b) in human plasma in pancreatic cancer patients. Our LSPR-based measurements showed that the miR levels measured directly in patient plasma were at least 2-fold higher than following RNA extraction and quantification by reverse transcriptase-polymerase chain reaction. Through LSPR-based measurements we have shown nearly 4-fold higher concentrations of miR-10b than miR-21 in plasma of pancreatic cancer patients. We propose that our highly sensitive and selective detection approach for assaying miRs in plasma can be applied to many cancer types and disease states and should allow a rational approach for testing the utility of miRs as markers for early disease diagnosis and prognosis, which could allow for the design of effective individualized therapeutic approaches. Twit Text FOAVip Highly specific plasmonic biosensors for ultrasensitive microRNA detection in plasma from pancreatic cancer patients ????Nano Lett http://www.kidney.de/pget.php?&tw=1&pmid=25379951 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25379951 #FOAvip English Wikipedia <ref>{{Cite pmid|25379951 }}</ref> Highly specific plasmonic biosensors for ultrasensitive microRNA detection in plasma from pancreatic cancer patients #MMPMID25379951 Joshi GK ; Deitz-McElyea S ; Johnson M ; Mali S ; Korc M ; Sardar R Nano Lett 2014[Dec]; 14 (12 ): 6955-63 PMID25379951 show ga MicroRNAs (miRs) are small noncoding RNAs that regulate mRNA stability and/or translation. Because of their release into the circulation and their remarkable stability, miR levels in plasma and other biological fluids can serve as diagnostic and prognostic disease biomarkers. However, quantifying miRs in the circulation is challenging due to issues with sensitivity and specificity. This Letter describes for the first time the design and characterization of a regenerative, solid-state localized surface plasmon resonance (LSPR) sensor based on highly sensitive nanostructures (gold nanoprisms) that obviates the need for labels or amplification of the miRs. Our direct hybridization approach has enabled the detection of subfemtomolar concentration of miR-X (X = 21 and 10b) in human plasma in pancreatic cancer patients. Our LSPR-based measurements showed that the miR levels measured directly in patient plasma were at least 2-fold higher than following RNA extraction and quantification by reverse transcriptase-polymerase chain reaction. Through LSPR-based measurements we have shown nearly 4-fold higher concentrations of miR-10b than miR-21 in plasma of pancreatic cancer patients. We propose that our highly sensitive and selective detection approach for assaying miRs in plasma can be applied to many cancer types and disease states and should allow a rational approach for testing the utility of miRs as markers for early disease diagnosis and prognosis, which could allow for the design of effective individualized therapeutic approaches. |Biomarkers, Tumor/*blood [MESH] |Biosensing Techniques/*instrumentation [MESH] |Equipment Design [MESH] |Equipment Failure Analysis [MESH] |Gold/chemistry [MESH] |Humans [MESH] |Metal Nanoparticles/chemistry/ultrastructure [MESH] |MicroRNAs/*blood [MESH] |Microchemistry/instrumentation [MESH] |Pancreatic Neoplasms/*blood/genetics/*metabolism [MESH] |Reproducibility of Results [MESH] |Sensitivity and Specificity [MESH]Highly specific plasmonic biosensors for ultrasensitive microRNA detec(epmc).pdf DeepDyve Pubget Overpricing