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10.1074/jbc.M114.571000 http://scihub22266oqcxt.onion/10.1074/jbc.M114.571000 C4263886!4263886 !25217645     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25217645 &cmd=llinks): Failed to open stream: HTTP request failed! 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GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling |pdf=|usr=}}{{25217645 }} gab.com Text GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25217645 #FOAvip Angiogenesis, the formation of new blood vessels from pre-existing ones, is essential for development, wound healing, and tumor progression. The VEGF pathway plays irreplaceable roles during angiogenesis, but how other signals cross-talk with and modulate VEGF cascades is not clearly elucidated. Here, we identified that Gpr126, an endothelial cell-enriched gene, plays an important role in angiogenesis by regulating endothelial cell proliferation, migration, and tube formation. Knockdown of Gpr126 in the mouse retina resulted in the inhibition of hypoxia-induced angiogenesis. Interference of Gpr126 expression in zebrafish embryos led to defects in intersegmental vessel formation. Finally, we identified that GPR126 regulated the expression of VEGFR2 by targeting STAT5 and GATA2 through the cAMP-PKA-cAMP-response element-binding protein signaling pathway during angiogenesis. Our findings illustrate that GPR126 modulates both physiological and pathological angiogenesis through VEGF signaling, providing a potential target for the treatment of angiogenesis-related diseases. Twit Text FOAVip GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25217645 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25217645 #FOAvip English Wikipedia <ref>{{Cite pmid|25217645 }}</ref> GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling #MMPMID25217645 Cui H ; Wang Y ; Huang H ; Yu W ; Bai M ; Zhang L ; Bryan BA ; Wang Y ; Luo J ; Li D ; Ma Y ; Liu M J Biol Chem 2014[Dec]; 289 (50 ): 34871-85 PMID25217645 show ga Angiogenesis, the formation of new blood vessels from pre-existing ones, is essential for development, wound healing, and tumor progression. The VEGF pathway plays irreplaceable roles during angiogenesis, but how other signals cross-talk with and modulate VEGF cascades is not clearly elucidated. Here, we identified that Gpr126, an endothelial cell-enriched gene, plays an important role in angiogenesis by regulating endothelial cell proliferation, migration, and tube formation. Knockdown of Gpr126 in the mouse retina resulted in the inhibition of hypoxia-induced angiogenesis. Interference of Gpr126 expression in zebrafish embryos led to defects in intersegmental vessel formation. Finally, we identified that GPR126 regulated the expression of VEGFR2 by targeting STAT5 and GATA2 through the cAMP-PKA-cAMP-response element-binding protein signaling pathway during angiogenesis. Our findings illustrate that GPR126 modulates both physiological and pathological angiogenesis through VEGF signaling, providing a potential target for the treatment of angiogenesis-related diseases. |*Signal Transduction [MESH] |Animals [MESH] |Cell Line [MESH] |Cell Movement [MESH] |Cell Proliferation [MESH] |Cyclic AMP/metabolism [MESH] |Embryonic Development [MESH] |Endothelial Cells/cytology/drug effects [MESH] |GATA2 Transcription Factor/metabolism [MESH] |Gene Expression Regulation [MESH] |Gene Knockdown Techniques [MESH] |Gene Silencing [MESH] |Humans [MESH] |Mice [MESH] |Neovascularization, Pathologic/genetics/*metabolism/*pathology [MESH] |Receptors, G-Protein-Coupled/deficiency/genetics/*metabolism [MESH] |STAT5 Transcription Factor/metabolism [MESH] |Transcription, Genetic [MESH] |Vascular Endothelial Growth Factor Receptor-2/*metabolism [MESH]GPR126 protein regulates developmental and pathological angiogenesis t(epmc).pdf DeepDyve Pubget Overpricing