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10.1074/jbc.M114.592774

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C4263870!4263870!25331955
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suck abstract from ncbi


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pmid25331955      J+Biol+Chem 2014 ; 289 (50): 34642-53
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  • Molecular Mechanisms of Calcium-sensing Receptor-mediated Calcium Signaling in the Modulation of Epithelial Ion Transport and Bicarbonate Secretion* #MMPMID25331955
  • Xie R; Dong X; Wong C; Vallon V; Tang B; Sun J; Yang S; Dong H
  • J Biol Chem 2014[Dec]; 289 (50): 34642-53 PMID25331955show ga
  • Background: Calcium-sensing receptor (CaSR) plays a critical role in the regulation of epithelial ion transport.Results: CaSR activators induce Ca2+ signaling and duodenal bicarbonate secretion (DBS).Conclusion: CaSR triggers Ca2+-dependent DBS, likely through receptor-operated channels, intermediate conductance Ca2+-activated K+ channels, and the cystic fibrosis transmembrane conductance regulator.Significance: Dietary CaSR activators may modulate the physiological process of DBS that is critical for duodenal mucosal protection.
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