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10.1074/jbc.R114.595439

http://scihub22266oqcxt.onion/10.1074/jbc.R114.595439
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C4263851!4263851!25336654
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suck abstract from ncbi


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pmid25336654      J+Biol+Chem 2014 ; 289 (50): 34440-8
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  • O-GlcNAc and the Epigenetic Regulation of Gene Expression* #MMPMID25336654
  • Lewis BA; Hanover JA
  • J Biol Chem 2014[Dec]; 289 (50): 34440-8 PMID25336654show ga
  • O-GlcNAcylation is an abundant nutrient-driven modification linked to cellular signaling and regulation of gene expression. Utilizing precursors derived from metabolic flux, O-GlcNAc functions as a homeostatic regulator. The enzymes of O-GlcNAc cycling, OGT and O-GlcNAcase, act in mitochondria, the cytoplasm, and the nucleus in association with epigenetic ?writers? and ?erasers? of the histone code. Both O-GlcNAc and O-phosphate modify repeats within the RNA polymerase II C-terminal domain (CTD). By communicating with the histone and CTD codes, O-GlcNAc cycling provides a link between cellular metabolic status and the epigenetic machinery. Thus, O-GlcNAcylation is poised to influence trans-generational epigenetic inheritance.
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