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10.1016/j.bbadis.2014.07.010 http://scihub22266oqcxt.onion/10.1016/j.bbadis.2014.07.010 C4262541!4262541!25064591     free     free     free       Biochim+Biophys+Acta 2014 ; 1842 (12 0 0): 2584-92 Nephropedia Template TP {{tp|p=25064591|t=2014. Soluble Adenylyl Cyclase in Health and Disease |pdf=|usr=}}{{25064591}} gab.com Text Soluble Adenylyl Cyclase in Health and Disease JO: Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=25064591 #FOAvip The second messenger cAMP is integral for many physiological processes. Soluble adenylyl cyclase (sAC) was recently identified as a widely expressed intracellular source of cAMP in mammalian cells. sAC is evolutionary, structurally, and biochemically distinct from the G-protein-responsive transmembranous adenylyl cyclases (tmAC). The structure of the catalytic unit of sAC is similar to tmAC, but sAC does not contain transmembranous domains, allowing localizations independent of the membranous compartment. sAC activity is stimulated by HCO3-, Ca2+ and is sensitive to physiologically relevant ATP fluctuations. sAC functions as a physiological sensor for carbon dioxide and bicarbonate, and therefore indirectly for pH. Here we review the physiological role of sAC in different human tissues with a major focus on the lung. Twit Text FOAVip Soluble Adenylyl Cyclase in Health and Disease ????Biochim Biophys Acta http://www.kidney.de/pget.php?&tw=1&pmid=25064591 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25064591 #FOAvip English Wikipedia <ref>{{Cite pmid|25064591}}</ref> Soluble Adenylyl Cyclase in Health and Disease #MMPMID25064591 Schmid A; Meili D; Salathe M Biochim Biophys Acta 2014[Dec]; 1842 (12 0 0): 2584-92 PMID25064591show ga The second messenger cAMP is integral for many physiological processes. Soluble adenylyl cyclase (sAC) was recently identified as a widely expressed intracellular source of cAMP in mammalian cells. sAC is evolutionary, structurally, and biochemically distinct from the G-protein-responsive transmembranous adenylyl cyclases (tmAC). The structure of the catalytic unit of sAC is similar to tmAC, but sAC does not contain transmembranous domains, allowing localizations independent of the membranous compartment. sAC activity is stimulated by HCO3-, Ca2+ and is sensitive to physiologically relevant ATP fluctuations. sAC functions as a physiological sensor for carbon dioxide and bicarbonate, and therefore indirectly for pH. Here we review the physiological role of sAC in different human tissues with a major focus on the lung. äSoluble Adenylyl Cyclase in Health and Disease (epmc).pdf DeepDyve Pubget Overpricing