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10.1016/j.jaci.2014.08.018

http://scihub22266oqcxt.onion/10.1016/j.jaci.2014.08.018
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C4260987!4260987!25280385
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suck abstract from ncbi


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pmid25280385      J+Allergy+Clin+Immunol 2014 ; 134 (6): 1318-1328.e7
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  • Fatal anaphylaxis in the United States 1999-2010: temporal patterns and demographic associations #MMPMID25280385
  • Jerschow E; Lin RY; Scaperotti MM; McGinn AP
  • J Allergy Clin Immunol 2014[Dec]; 134 (6): 1318-1328.e7 PMID25280385show ga
  • Background: Anaphylaxis-related deaths in the United States (US) have not been well characterized in recent years. Objectives: To define epidemiological features and time trends of fatal anaphylaxis in the US from 1999 to 2010. Methods: Anaphylaxis-related deaths were identified by the 10th clinical modification of the International Classification of Diseases (ICD-10) system diagnostic codes on death certificates from the US National Mortality Database. Rates were calculated using census population estimates. Results: There were a total of 2,458 anaphylaxis deaths in the US from 1999 to 2010. Medications were the most common cause (58.8%), followed by unspecified anaphylaxis (19.3%), venom (15.2%), and food (6.7%). There was a significant increase in fatal drug anaphylaxis over twelve years: from 0.27 (95%CI: 0.23-0.30) in 1999-2001 to 0.51 (95%CI: 0.47-0.56) per million in 2008-2010, P<0.001. Fatal anaphylaxis due to medications, food, and unspecified allergens was significantly associated with African-American race and older age, P<0.001. Fatal anaphylaxis to venom was significantly associated with White race, older age, and male gender, P<0.001. The rates of fatal anaphylaxis to foods in African-American males increased from 0.06 (95%CI 0.01-0.17) in 1999-2001 to 0.21 (95%CI 0.11-0.37) per million in 2008-2010, P<0.001. The rates of unspecified fatal anaphylaxis decreased overtime from 0.30 (95%CI: 0.26-0.34) in 1999-2001 to 0.09 (95%CI: 0.07-0.11) per million in 2008-2010, P<0.001. Conclusion: There are strong and disparate associations between race and specific classes of anaphylaxis mortality in the United States. The increase in medication-related anaphylaxis deaths likely relates to increased medication and radiocontrast use, enhanced diagnosis, and coding changes.
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