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Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Expert+Rev+Anticancer+Ther 2014 ; 14 (12): 1411-8 Nephropedia Template TP
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Nanotube x-ray for cancer therapy: a compact microbeam radiation therapy system for brain tumor treatment #MMPMID25417729
Zhang L; Yuan H; Inscoe C; Chtcheprov P; Hadsell M; Lee Y; Lu J; Chang S; Zhou O
Expert Rev Anticancer Ther 2014[Dec]; 14 (12): 1411-8 PMID25417729show ga
Microbeam radiation therapy (MRT) is a promising preclinical modality for cancer treatment, with remarkable preferential tumoricidal effects, that is, tumor eradication without damaging normal tissue functions. Significant lifespan extension has been demonstrated in brain tumor-bearing small animals treated with MRT. So far, MRT experiments can only be performed in a few synchrotron facilities around the world. Limited access to MRT facilities prevents this enormously promising radiotherapy technology from reaching the broader biomedical research community and hinders its potential clinical translation. We recently demonstrated, for the first time, the feasibility of generating microbeam radiation in a laboratory environment using a carbon nanotube x-ray source array and performed initial small animal studies with various brain tumor models. This new nanotechnology-enabled microbeam delivery method, although still in its infancy, has shown promise for achieving comparable therapeutic effects to synchrotron MRT and has offered a potential pathway for clinical translation.