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2014 ; 14
(12
): 1411-8
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Nanotube x-ray for cancer therapy: a compact microbeam radiation therapy system
for brain tumor treatment
#MMPMID25417729
Zhang L
; Yuan H
; Inscoe C
; Chtcheprov P
; Hadsell M
; Lee Y
; Lu J
; Chang S
; Zhou O
Expert Rev Anticancer Ther
2014[Dec]; 14
(12
): 1411-8
PMID25417729
show ga
Microbeam radiation therapy (MRT) is a promising preclinical modality for cancer
treatment, with remarkable preferential tumoricidal effects, that is, tumor
eradication without damaging normal tissue functions. Significant lifespan
extension has been demonstrated in brain tumor-bearing small animals treated with
MRT. So far, MRT experiments can only be performed in a few synchrotron
facilities around the world. Limited access to MRT facilities prevents this
enormously promising radiotherapy technology from reaching the broader biomedical
research community and hinders its potential clinical translation. We recently
demonstrated, for the first time, the feasibility of generating microbeam
radiation in a laboratory environment using a carbon nanotube x-ray source array
and performed initial small animal studies with various brain tumor models. This
new nanotechnology-enabled microbeam delivery method, although still in its
infancy, has shown promise for achieving comparable therapeutic effects to
synchrotron MRT and has offered a potential pathway for clinical translation.