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10.1073/pnas.1412285111 http://scihub22266oqcxt.onion/10.1073/pnas.1412285111 C4260597!4260597!25404288     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (48): 17176-81 Nephropedia Template TP {{tp|p=25404288|t=2014. Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area |pdf=|usr=}}{{25404288}} gab.com Text Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25404288 #FOAvip Mechanical properties of the extracellular environment provide important cues that regulate cell behavior. Understanding this mechanical signaling has become important in disease treatment as well as tissue engineering. To efficiently study cellular responses to rigidity signals, we have created a model system of micropatterned composite material based on the ?cell-on-a-chip? concept. We demonstrate that a migrating fibroblast uses filopodia to probe substrate rigidity, such that it ?feels? its way based on the deformability of a material before occupying an area. Myosin II plays a key role in rigidity sensing and responses. This mechanism allows cells to migrate efficiently by avoiding mechanically unfavorable areas without backtracking. Twit Text FOAVip Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25404288 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25404288 #FOAvip English Wikipedia <ref>{{Cite pmid|25404288}}</ref> Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area #MMPMID25404288 Wong S; Guo WH; Wang YL Proc Natl Acad Sci U S A 2014[Dec]; 111 (48): 17176-81 PMID25404288show ga Mechanical properties of the extracellular environment provide important cues that regulate cell behavior. Understanding this mechanical signaling has become important in disease treatment as well as tissue engineering. To efficiently study cellular responses to rigidity signals, we have created a model system of micropatterned composite material based on the ?cell-on-a-chip? concept. We demonstrate that a migrating fibroblast uses filopodia to probe substrate rigidity, such that it ?feels? its way based on the deformability of a material before occupying an area. Myosin II plays a key role in rigidity sensing and responses. This mechanism allows cells to migrate efficiently by avoiding mechanically unfavorable areas without backtracking. äFibroblasts probe substrate rigidity with filopodia extensions before (epmc).pdf DeepDyve Pubget Overpricing