Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1412663111 http://scihub22266oqcxt.onion/10.1073/pnas.1412663111 C4260590!4260590 !25404305     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25404305 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (48 ): E5169-77 Nephropedia Template TP {{tp|p=25404305 |t=2014. Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion |pdf=|usr=}}{{25404305 }} gab.com Text Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25404305 #FOAvip Basophils orchestrate protection against reinfections with gastrointestinal helminths and ticks, but the underlying mechanisms remain elusive. We investigated the role of Fc receptors on basophils, the antibody isotypes IgG1 and IgE, and basophil-derived IL-4/IL-13 during challenge infections with Heligmosomoides polygyrus and Nippostrongylus brasiliensis. Using mixed bone marrow chimeras, we found that activating Fc receptors on basophils were required for protective immunity but not for regulation of basophil homeostasis. Furthermore, rapid worm expulsion was impaired in IgE-deficient but not in IgG1-deficient mice. Basophils promoted the recruitment of other effector cells into the small intestine and induced expression of the antihelminthic proteins resistin-like molecule ? and mucin 5ac. Selective deletion of IL-4/IL-13 in basophils resulted in impaired worm expulsion. Collectively, our results indicate that IgE-mediated activation of basophils and the release of basophil-derived IL-4/IL-13 are critical steps in protective immunity against helminths. Therefore, development of effective vaccines against helminths should consider boosting the IL-4/IgE/basophil axis of the immune system. Twit Text FOAVip Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25404305 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25404305 #FOAvip English Wikipedia <ref>{{Cite pmid|25404305 }}</ref> Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion #MMPMID25404305 Schwartz C ; Turqueti-Neves A ; Hartmann S ; Yu P ; Nimmerjahn F ; Voehringer D Proc Natl Acad Sci U S A 2014[Dec]; 111 (48 ): E5169-77 PMID25404305 show ga Basophils orchestrate protection against reinfections with gastrointestinal helminths and ticks, but the underlying mechanisms remain elusive. We investigated the role of Fc receptors on basophils, the antibody isotypes IgG1 and IgE, and basophil-derived IL-4/IL-13 during challenge infections with Heligmosomoides polygyrus and Nippostrongylus brasiliensis. Using mixed bone marrow chimeras, we found that activating Fc receptors on basophils were required for protective immunity but not for regulation of basophil homeostasis. Furthermore, rapid worm expulsion was impaired in IgE-deficient but not in IgG1-deficient mice. Basophils promoted the recruitment of other effector cells into the small intestine and induced expression of the antihelminthic proteins resistin-like molecule ? and mucin 5ac. Selective deletion of IL-4/IL-13 in basophils resulted in impaired worm expulsion. Collectively, our results indicate that IgE-mediated activation of basophils and the release of basophil-derived IL-4/IL-13 are critical steps in protective immunity against helminths. Therefore, development of effective vaccines against helminths should consider boosting the IL-4/IgE/basophil axis of the immune system. |Animals [MESH] |Basophils/*immunology/metabolism/parasitology [MESH] |Blotting, Western [MESH] |Cytokines/*immunology/metabolism [MESH] |Flow Cytometry [MESH] |Gastrointestinal Tract/*immunology/metabolism/parasitology [MESH] |Heligmosomatoidea/*immunology/physiology [MESH] |Host-Parasite Interactions/immunology [MESH] |Immunoglobulin E/genetics/*immunology/metabolism [MESH] |Interleukin-13/genetics/immunology/metabolism [MESH] |Interleukin-4/genetics/immunology/metabolism [MESH] |Intestine, Small/immunology/metabolism/parasitology [MESH] |Mice, Inbred BALB C [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mice, Transgenic [MESH] |Nematospiroides dubius/immunology/physiology [MESH] |Nippostrongylus/immunology/physiology [MESH] |Receptors, Fc/genetics/immunology/metabolism [MESH] |Strongylida Infections/*immunology/metabolism/parasitology [MESH]Basophil-mediated protection against gastrointestinal helminths requir(epmc).pdf DeepDyve Pubget Overpricing