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10.1073/pnas.1420193111

http://scihub22266oqcxt.onion/10.1073/pnas.1420193111
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C4260545!4260545!25404328
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suck abstract from ncbi


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pmid25404328      Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (48): 17206-11
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  • Reducing the genetic code induces massive rearrangement of the proteome #MMPMID25404328
  • O?Donoghue P; Prat L; Kucklick M; Schäfer JG; Riedel K; Rinehart J; Söll D; Heinemann IU
  • Proc Natl Acad Sci U S A 2014[Dec]; 111 (48): 17206-11 PMID25404328show ga
  • Expanding the genetic code is an important aim of synthetic biology, but some organisms developed naturally expanded genetic codes over the course of evolution. To understand the selective advantage of genetically encoding more than 20 amino acids, we investigated the proteome-wide response to reducing the genetic code of Methanosarcina acetivorans from 21 to 20 amino acids. The data show how a natural proteome adapts to genetic code reduction and indicate that the selective value of an expanded genetic code is related to carbon source range and metabolic efficiency.
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