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10.1073/pnas.1402724111 http://scihub22266oqcxt.onion/10.1073/pnas.1402724111 C4260541!4260541!25411315     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25411315&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 500 Internal Server Error in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2014 ; 111 (48): 17248-53 Nephropedia Template TP {{tp|p=25411315|t=2014. Optimal T-cell receptor affinity for inducing autoimmunity |pdf=|usr=}}{{25411315}} gab.com Text Optimal T-cell receptor affinity for inducing autoimmunity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25411315 #FOAvip The adaptive immune system has the potential to generate a self-reactive response, which can eventually lead to an autoimmune disease. To avoid this outcome, T lymphocytes with high-affinity, self-reactive antigen receptors are blocked from entering the mature T-cell pool (negative selection). Given this mechanism for removing dangerous high-affinity T cells, we wondered whether autoimmunity is more likely to be caused by chronic stimulation of low-affinity T cells or by stimulation of a few high-affinity T cells that escaped negative selection. In this paper, we show that T cells with an affinity just above the selection threshold can bypass negative selection and have the highest potential to cause an experimental autoimmune disease. Twit Text FOAVip Optimal T-cell receptor affinity for inducing autoimmunity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25411315 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25411315 #FOAvip English Wikipedia <ref>{{Cite pmid|25411315}}</ref> Optimal T-cell receptor affinity for inducing autoimmunity #MMPMID25411315 Koehli S; Naeher D; Galati-Fournier V; Zehn D; Palmer E Proc Natl Acad Sci U S A 2014[Dec]; 111 (48): 17248-53 PMID25411315show ga The adaptive immune system has the potential to generate a self-reactive response, which can eventually lead to an autoimmune disease. To avoid this outcome, T lymphocytes with high-affinity, self-reactive antigen receptors are blocked from entering the mature T-cell pool (negative selection). Given this mechanism for removing dangerous high-affinity T cells, we wondered whether autoimmunity is more likely to be caused by chronic stimulation of low-affinity T cells or by stimulation of a few high-affinity T cells that escaped negative selection. In this paper, we show that T cells with an affinity just above the selection threshold can bypass negative selection and have the highest potential to cause an experimental autoimmune disease. äOptimal T-cell receptor affinity for inducing autoimmunity (epmc).pdf DeepDyve Pubget Overpricing