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10.1038/bjc.2014.528 http://scihub22266oqcxt.onion/10.1038/bjc.2014.528 C4260038!4260038 !25321191     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25321191 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Br+J+Cancer 2014 ; 111 (11 ): 2122-30 Nephropedia Template TP {{tp|p=25321191 |t=2014. SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma |pdf=|usr=}}{{25321191 }} gab.com Text SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma JO: Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25321191 #FOAvip BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) display cellular heterogeneity and contain cancer stem cells (CSCs). Sex-determining region Y [SRY]-box (SOX)2 is an important regulator of embryonic stem cell fate and is aberrantly expressed in several types of human tumours. Nonetheless, the role of SOX2 in HNSCC remains unclear. METHODS: We created cells ectopically expressing SOX2 from previously established HNSCC cells and examined the cell proliferation, self-renewal capacity, and chemoresistance of these cells compared with control cells. In addition, we knocked down SOX2 in primary spheres obtained from HNSCC tumour tissue and assessed the attenuation of stemness-associated traits in these cells in vitro and in vivo. Furthermore, we examined the clinical relevance of SOX2 expression in HNSCC patients. RESULTS: SOX2 is aberrantly expressed in primary tissue of HNSCC patients but not in healthy tissue. SOX2 expression correlated with tumour recurrence and poor prognosis of HNSCC patients. Ectopic expression of SOX2 induced cell proliferation via cyclin B1 expression and stemness-associated features, such as self-renewal and chemoresistance. In addition, a knockdown of SOX2 in HNSCC CSCs attenuated their self-renewal capacity, chemoresistance (through ABCG2 suppression), invasion capacity (via snail downregulation), and in vivo tumorigenicity. CONCLUSIONS: These results suggest that SOX2 may have important roles in the 'stemness' and progression of HNSCC. Targeting SOX2-positive tumour cells (CSCs) could be a new therapeutic strategy in HNSCCs. Twit Text FOAVip SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma ????Br J Cancer http://www.kidney.de/pget.php?&tw=1&pmid=25321191 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25321191 #FOAvip English Wikipedia <ref>{{Cite pmid|25321191 }}</ref> SOX2 regulates self-renewal and tumorigenicity of stem-like cells of head and neck squamous cell carcinoma #MMPMID25321191 Lee SH ; Oh SY ; Do SI ; Lee HJ ; Kang HJ ; Rho YS ; Bae WJ ; Lim YC Br J Cancer 2014[Nov]; 111 (11 ): 2122-30 PMID25321191 show ga BACKGROUND: Head and neck squamous cell carcinomas (HNSCCs) display cellular heterogeneity and contain cancer stem cells (CSCs). Sex-determining region Y [SRY]-box (SOX)2 is an important regulator of embryonic stem cell fate and is aberrantly expressed in several types of human tumours. Nonetheless, the role of SOX2 in HNSCC remains unclear. METHODS: We created cells ectopically expressing SOX2 from previously established HNSCC cells and examined the cell proliferation, self-renewal capacity, and chemoresistance of these cells compared with control cells. In addition, we knocked down SOX2 in primary spheres obtained from HNSCC tumour tissue and assessed the attenuation of stemness-associated traits in these cells in vitro and in vivo. Furthermore, we examined the clinical relevance of SOX2 expression in HNSCC patients. RESULTS: SOX2 is aberrantly expressed in primary tissue of HNSCC patients but not in healthy tissue. SOX2 expression correlated with tumour recurrence and poor prognosis of HNSCC patients. Ectopic expression of SOX2 induced cell proliferation via cyclin B1 expression and stemness-associated features, such as self-renewal and chemoresistance. In addition, a knockdown of SOX2 in HNSCC CSCs attenuated their self-renewal capacity, chemoresistance (through ABCG2 suppression), invasion capacity (via snail downregulation), and in vivo tumorigenicity. CONCLUSIONS: These results suggest that SOX2 may have important roles in the 'stemness' and progression of HNSCC. Targeting SOX2-positive tumour cells (CSCs) could be a new therapeutic strategy in HNSCCs. |ATP Binding Cassette Transporter, Subfamily G, Member 2 [MESH] |ATP-Binding Cassette Transporters/physiology [MESH] |Animals [MESH] |Carcinogenesis [MESH] |Carcinoma, Squamous Cell/drug therapy/mortality/*pathology [MESH] |Cell Line, Tumor [MESH] |Cell Proliferation [MESH] |Cyclin B1/physiology [MESH] |Drug Resistance, Neoplasm [MESH] |Epithelial-Mesenchymal Transition [MESH] |Head and Neck Neoplasms/drug therapy/mortality/*pathology [MESH] |Humans [MESH] |Mice [MESH] |Neoplasm Invasiveness [MESH] |Neoplasm Proteins/physiology [MESH] |Neoplastic Stem Cells/*pathology [MESH] |SOXB1 Transcription Factors/*physiology [MESH]SOX2 regulates self-renewal and tumorigenicity of stem-like cells of h(epmc).pdf DeepDyve Pubget Overpricing