Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.4049/jimmunol.1401798 http://scihub22266oqcxt.onion/10.4049/jimmunol.1401798 C4259264!4259264!25362179     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 193 (11): 5515-24 Nephropedia Template TP {{tp|p=25362179|t=2014. Deleted in Breast Cancer 1 (DBC1) is a Suppressor of B cell Activation by Negatively Regulating Alternative NF-?B Transcriptional Activity |pdf=|usr=}}{{25362179}} gab.com Text Deleted in Breast Cancer 1 (DBC1) is a Suppressor of B cell Activation by Negatively Regulating Alternative NF- B Transcriptional Activity JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25362179 #FOAvip CD40 and BAFF receptor (BAFFR) signaling plays important roles in B cell proliferation and immunoglobulin production. In this study we found that B cells from mice with deletion of Dbc1 gene (Dbc1?/?) show elevated proliferation, and IgG1 and IgA production upon in vitro CD40 and BAFF, but not BCR and LPS stimulation, indicating that DBC1 inhibits CD40/BAFF-mediated B cell activation in a cell-intrinsic manner. Microarray analysis and Chromatin Immunoprecipitation (ChIP) experiments reveal that DBC1 inhibits B cell function by selectively suppressing the transcriptional activity of alternative NF-?B members RelB and p52 upon CD40 stimulation. As a result, when immunized with Nitrophenylated-Keyhole Limpet Hemocyanin (NP-KLH), Dbc1?/? mice produce significantly increased levels of germinal center B cells, plasma cells, as well as antigen-specific immunoglobulin. Finally, loss of DBC1 in mice leads to higher susceptibility to Experimental Autoimmune Myasthenia Gravis (EAMG). Our study identifies DBC1 as a novel regulator of B cell activation by suppressing the alternative NF-?B pathway. Twit Text FOAVip Deleted in Breast Cancer 1 (DBC1) is a Suppressor of B cell Activation by Negatively Regulating Alternative NF- B Transcriptional Activity ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25362179 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25362179 #FOAvip English Wikipedia <ref>{{Cite pmid|25362179}}</ref> Deleted in Breast Cancer 1 (DBC1) is a Suppressor of B cell Activation by Negatively Regulating Alternative NF-?B Transcriptional Activity #MMPMID25362179 Kong S; Thiruppathi M; Qiu Q; Lin Z; Dong H; Chini EN; Prabhakar BS; Fang. D J Immunol 2014[Dec]; 193 (11): 5515-24 PMID25362179show ga CD40 and BAFF receptor (BAFFR) signaling plays important roles in B cell proliferation and immunoglobulin production. In this study we found that B cells from mice with deletion of Dbc1 gene (Dbc1?/?) show elevated proliferation, and IgG1 and IgA production upon in vitro CD40 and BAFF, but not BCR and LPS stimulation, indicating that DBC1 inhibits CD40/BAFF-mediated B cell activation in a cell-intrinsic manner. Microarray analysis and Chromatin Immunoprecipitation (ChIP) experiments reveal that DBC1 inhibits B cell function by selectively suppressing the transcriptional activity of alternative NF-?B members RelB and p52 upon CD40 stimulation. As a result, when immunized with Nitrophenylated-Keyhole Limpet Hemocyanin (NP-KLH), Dbc1?/? mice produce significantly increased levels of germinal center B cells, plasma cells, as well as antigen-specific immunoglobulin. Finally, loss of DBC1 in mice leads to higher susceptibility to Experimental Autoimmune Myasthenia Gravis (EAMG). Our study identifies DBC1 as a novel regulator of B cell activation by suppressing the alternative NF-?B pathway. äDeleted in Breast Cancer 1 (DBC1) is a Suppressor of B cell Activation(epmc).pdf DeepDyve Pubget Overpricing