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10.1089/vim.2014.0077

http://scihub22266oqcxt.onion/10.1089/vim.2014.0077
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suck abstract from ncbi


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pmid25479178
      Viral+Immunol 2014 ; 27 (10 ): 484-96
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  • Intraepithelial T-cell cytotoxicity, induced bronchus-associated lymphoid tissue, and proliferation of pneumocytes in experimental mouse models of influenza #MMPMID25479178
  • Sell S ; Guest I ; McKinstry KK ; Strutt TM ; Kohlmeier JE ; Brincks E ; Tighe M ; Blackman MA ; Woodland DL ; Dutton RW ; Swain SL
  • Viral Immunol 2014[Dec]; 27 (10 ): 484-96 PMID25479178 show ga
  • Immunopathologic examination of the lungs of mice with experimental influenza virus infection reveals three prominent findings. (i) There is rapidly developing perivascular (arterial) and peribronchial infiltration with T-cells and invasion of T-cells into the bronchiolar epithelium, separation of epithelial cells from each other and from the basement membrane, leading to defoliation of the bronchial epithelium. This reaction is analogous to a viral exanthema of the skin, such as measles and smallpox. This previously described but unappreciated reaction most likely is an effective way to eliminate virus-infected cells, but may contribute to acute toxicity and mortality. (ii) After this, there is formation of dense collections of lymphocytes adjacent to bronchi consisting mainly of B-cells, with a scattering of T-cells and macrophages. This is known as induced bronchial-associated lymphoid tissue (iBALT) and correlates with increased interleukin (IL)-17 in the lung. iBALT provides sites for a local immune reaction in the lung to both the original infection and related viral infections (heterologous immunity). (iii) Within the first 2-3 weeks, there is proliferation of type II pneumocytes and/or terminal bronchial epithelial cells extending from the terminal bronchioles into the adjacent alveoli, eventually leading to large zones of the lung filled with tumor-like epithelial cells with squamous metaplasia. The proliferation correlates with IL-17 and IL-22 expression, and the extent of this reaction appears to be determined by the availability of T-regulatory cells.
  • |*Cell Proliferation [MESH]
  • |Alveolar Epithelial Cells/*physiology [MESH]
  • |Animals [MESH]
  • |Bronchi/immunology/pathology [MESH]
  • |Disease Models, Animal [MESH]
  • |Lung/immunology/pathology [MESH]
  • |Lymphoid Tissue/immunology/*pathology [MESH]
  • |Mice [MESH]
  • |Orthomyxoviridae Infections/immunology/*pathology [MESH]
  • |Respiratory Mucosa/immunology/*pathology [MESH]


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