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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Immunol
2014 ; 193
(12
): 5772-8
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The plasmacytoid dendritic cell as the Swiss army knife of the immune system:
molecular regulation of its multifaceted functions
#MMPMID25480956
J Immunol
2014[Dec]; 193
(12
): 5772-8
PMID25480956
show ga
Plasmacytoid dendritic cells (pDC) have been regarded as the "professional type I
IFN-producing cells" of the immune system following viral recognition that relies
on the expression of TLR7 and TLR9. Furthermore, pDC link the innate and adaptive
immune systems via cytokine production and Ag presentation. More recently, their
ability to induce tolerance and cytotoxicity has been added to their "immune
skills." Such a broad range of actions, resembling the diverse functional
features of a Swiss army knife, requires strong and prompt molecular regulation
to prevent detrimental effects, including autoimmune pathogenesis or tumor
escape. Over the last decades, we and other investigators have started to unravel
some aspects of the signaling pathways that regulate the various functions of
human pDC. In this article, we review aspects of the molecular regulatory
mechanisms to control pDC function in light of their multifaceted roles during
immunity, autoimmunity, and cancer.