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10.1038/ncomms6698 http://scihub22266oqcxt.onion/10.1038/ncomms6698 C4258872!4258872!25474997     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2014 ; 5 (ä): 5698 Nephropedia Template TP {{tp|p=25474997|t=2014. Architecture and dynamic remodeling of the septin cytoskeleton during the cell cycle |pdf=|usr=}}{{25474997}} gab.com Text Architecture and dynamic remodeling of the septin cytoskeleton during the cell cycle JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25474997 #FOAvip Septins perform diverse functions through the formation of filaments and higher-order structures. However, the exact architecture of septin structures remains unclear. In the budding yeast Saccharomyces cerevisiae, septins form an ?hourglass? at the mother-bud neck before cytokinesis, which is converted into a ?double ring? during cytokinesis. Here, using platinum-replica electron microscopy, we find that the early hourglass consists of septin double filaments oriented along the mother-bud axis. In the late hourglass, these double filaments are connected by periodic circumferential single filaments on the membrane-proximal side, and are associated with centrally located, circumferential, myosin-II thick filaments on the membrane-distal side. The double ring consists of exclusively circumferential septin filaments. Live-cell imaging studies indicate that the hourglass-to-double ring transition is accompanied by loss of septin subunits from the hourglass, and reorganization of the remaining subunits into the double ring. This work provides an unparalleled view of septin structures within cells and defines their remodeling dynamics during the cell cycle. Twit Text FOAVip Architecture and dynamic remodeling of the septin cytoskeleton during the cell cycle ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=25474997 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25474997 #FOAvip English Wikipedia <ref>{{Cite pmid|25474997}}</ref> Architecture and dynamic remodeling of the septin cytoskeleton during the cell cycle #MMPMID25474997 Ong K; Wloka C; Okada S; Svitkina T; Bi E Nat Commun 2014[]; 5 (ä): 5698 PMID25474997show ga Septins perform diverse functions through the formation of filaments and higher-order structures. However, the exact architecture of septin structures remains unclear. In the budding yeast Saccharomyces cerevisiae, septins form an ?hourglass? at the mother-bud neck before cytokinesis, which is converted into a ?double ring? during cytokinesis. Here, using platinum-replica electron microscopy, we find that the early hourglass consists of septin double filaments oriented along the mother-bud axis. In the late hourglass, these double filaments are connected by periodic circumferential single filaments on the membrane-proximal side, and are associated with centrally located, circumferential, myosin-II thick filaments on the membrane-distal side. The double ring consists of exclusively circumferential septin filaments. Live-cell imaging studies indicate that the hourglass-to-double ring transition is accompanied by loss of septin subunits from the hourglass, and reorganization of the remaining subunits into the double ring. This work provides an unparalleled view of septin structures within cells and defines their remodeling dynamics during the cell cycle. äArchitecture and dynamic remodeling of the septin cytoskeleton during (epmc).pdf DeepDyve Pubget Overpricing