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10.1016/j.cell.2014.11.003 http://scihub22266oqcxt.onion/10.1016/j.cell.2014.11.003 C4258511!4258511!25467445     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2014 ; 159 (6): 1417-32 Nephropedia Template TP {{tp|p=25467445|t=2014. Identification of spinal circuits transmitting and gating mechanical pain |pdf=|usr=}}{{25467445}} gab.com Text Identification of spinal circuits transmitting and gating mechanical pain JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=25467445 #FOAvip Pain processing in the spinal cord has been postulated to rely on nociceptive transmission (T) neurons receiving inputs from nociceptors and A? mechanoreceptors, with A? inputs gated through feed-forward activation of spinal inhibitory neurons (IN). Here we used intersectional genetic manipulations to identify these critical components of pain transduction. Marking and ablating six populations of spinal excitatory and inhibitory neurons, coupled with behavioral and electrophysiological analysis, showed that excitatory neurons expressing somatostatin (SOM) represent T-type cells, whose ablation causes loss of mechanical pain. Inhibitory neurons marked by the expression of dynorphin (Dyn) represent IN-type neurons, which are necessary to gate A? fibers from activating SOM+ neurons to evoke pain. Therefore, peripheral mechanical nociceptors and A? mechanoreceptors, together with spinal SOM+ excitatory and Dyn+ inhibitory neurons form a microcircuit that transmits and gates mechanical pain. Twit Text FOAVip Identification of spinal circuits transmitting and gating mechanical pain ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=25467445 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25467445 #FOAvip English Wikipedia <ref>{{Cite pmid|25467445}}</ref> Identification of spinal circuits transmitting and gating mechanical pain #MMPMID25467445 Duan B; Cheng L; Bourane S; Britz O; Padilla C; Garcia-Campmany L; Krashes M; Knowlton W; Velasquez T; Ren X; Ross S; Lowell BB; Wang Y; Goulding M; Ma Q Cell 2014[Dec]; 159 (6): 1417-32 PMID25467445show ga Pain processing in the spinal cord has been postulated to rely on nociceptive transmission (T) neurons receiving inputs from nociceptors and A? mechanoreceptors, with A? inputs gated through feed-forward activation of spinal inhibitory neurons (IN). Here we used intersectional genetic manipulations to identify these critical components of pain transduction. Marking and ablating six populations of spinal excitatory and inhibitory neurons, coupled with behavioral and electrophysiological analysis, showed that excitatory neurons expressing somatostatin (SOM) represent T-type cells, whose ablation causes loss of mechanical pain. Inhibitory neurons marked by the expression of dynorphin (Dyn) represent IN-type neurons, which are necessary to gate A? fibers from activating SOM+ neurons to evoke pain. Therefore, peripheral mechanical nociceptors and A? mechanoreceptors, together with spinal SOM+ excitatory and Dyn+ inhibitory neurons form a microcircuit that transmits and gates mechanical pain. äIdentification of spinal circuits transmitting and gating mechanical p(epmc).pdf DeepDyve Pubget Overpricing