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10.1016/j.ajpath.2014.08.022 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2014.08.022 C4258504!4258504 !25300578     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25300578 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Pathol 2014 ; 184 (12 ): 3284-98 Nephropedia Template TP {{tp|p=25300578 |t=2014. ?-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice |pdf=|usr=}}{{25300578 }} gab.com Text -catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=25300578 #FOAvip ?-catenin regulates the establishment of hepatic metabolic zonation. To elucidate the functional significance of liver metabolic zonation in the chronically overfed state in vivo, we fed a high-fat diet (HFD) to hepatocyte-specific ?-catenin transgenic (TG) and knockout (KO) mice. Chow-fed TG and KO mice had normal liver histologic findings and body weight. However, HFD-fed TG mice developed prominent perivenous steatosis with periportal sparing. In contrast, HFD-fed KO mice had increased lobular inflammation and hepatocyte apoptosis. HFD-fed TG mice rapidly developed diet-induced obesity and systemic insulin resistance, but KO mice were resistant to diet-induced obesity. However, ?-catenin did not directly affect hepatic insulin signaling, suggesting that the metabolic effects of ?-catenin occurred via a parallel pathway. Hepatic expression of key glycolytic and lipogenic genes was higher in HFD-fed TG and lower in KO mice compared with wild-type mice. KO mice also exhibited defective hepatic fatty acid oxidation and fasting ketogenesis. Hepatic levels of hypoxia inducible factor-1?, an oxygen-sensitive transcriptional regulator of glycolysis and a known ?-catenin binding partner, were higher in HFD-fed TG and lower in KO mice. KO mice had attenuated perivenous hypoxia, suggesting disruption of the normal sinusoidal oxygen gradient, a major determinant of liver carbohydrate and liver metabolism. Canonical Wnt signaling in hepatocytes is essential for the development of diet-induced fatty liver and obesity. Twit Text FOAVip -catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=25300578 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25300578 #FOAvip English Wikipedia <ref>{{Cite pmid|25300578 }}</ref> ?-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice #MMPMID25300578 Behari J ; Li H ; Liu S ; Stefanovic-Racic M ; Alonso L ; O'Donnell CP ; Shiva S ; Singamsetty S ; Watanabe Y ; Singh VP ; Liu Q Am J Pathol 2014[Dec]; 184 (12 ): 3284-98 PMID25300578 show ga ?-catenin regulates the establishment of hepatic metabolic zonation. To elucidate the functional significance of liver metabolic zonation in the chronically overfed state in vivo, we fed a high-fat diet (HFD) to hepatocyte-specific ?-catenin transgenic (TG) and knockout (KO) mice. Chow-fed TG and KO mice had normal liver histologic findings and body weight. However, HFD-fed TG mice developed prominent perivenous steatosis with periportal sparing. In contrast, HFD-fed KO mice had increased lobular inflammation and hepatocyte apoptosis. HFD-fed TG mice rapidly developed diet-induced obesity and systemic insulin resistance, but KO mice were resistant to diet-induced obesity. However, ?-catenin did not directly affect hepatic insulin signaling, suggesting that the metabolic effects of ?-catenin occurred via a parallel pathway. Hepatic expression of key glycolytic and lipogenic genes was higher in HFD-fed TG and lower in KO mice compared with wild-type mice. KO mice also exhibited defective hepatic fatty acid oxidation and fasting ketogenesis. Hepatic levels of hypoxia inducible factor-1?, an oxygen-sensitive transcriptional regulator of glycolysis and a known ?-catenin binding partner, were higher in HFD-fed TG and lower in KO mice. KO mice had attenuated perivenous hypoxia, suggesting disruption of the normal sinusoidal oxygen gradient, a major determinant of liver carbohydrate and liver metabolism. Canonical Wnt signaling in hepatocytes is essential for the development of diet-induced fatty liver and obesity. |*Diet, High-Fat [MESH] |*Lipid Metabolism [MESH] |Animals [MESH] |Apoptosis [MESH] |Body Weight [MESH] |Fatty Acids/chemistry [MESH] |Fatty Liver/metabolism [MESH] |Glycolysis [MESH] |Hepatocytes/metabolism [MESH] |Hypoxia/metabolism [MESH] |Immunohistochemistry [MESH] |Inflammation [MESH] |Insulin Resistance [MESH] |Insulin/metabolism [MESH] |Liver/*metabolism [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mitochondria/metabolism [MESH] |Obesity/*metabolism [MESH] |Oxygen/chemistry [MESH] |Signal Transduction [MESH]?-catenin links hepatic metabolic zonation with lipid metabolism and d(epmc).pdf DeepDyve Pubget Overpricing