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10.1016/j.ajpath.2014.08.005 http://scihub22266oqcxt.onion/10.1016/j.ajpath.2014.08.005 C4258502!4258502 !25280631     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25280631 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Pathol 2014 ; 184 (12 ): 3299-307 Nephropedia Template TP {{tp|p=25280631 |t=2014. Uptake and degradation of protease-sensitive and -resistant forms of abnormal human prion protein aggregates by human astrocytes |pdf=|usr=}}{{25280631 }} gab.com Text Uptake and degradation of protease-sensitive and -resistant forms of abnormal human prion protein aggregates by human astrocytes JO: Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=25280631 #FOAvip Sporadic Creutzfeldt-Jakob disease is the most common of the human prion diseases, a group of rare, transmissible, and fatal neurologic diseases associated with the accumulation of an abnormal form (PrP(Sc)) of the host prion protein. In sporadic Creutzfeldt-Jakob disease, disease-associated PrP(Sc) is present not only as an aggregated, protease-resistant form but also as an aggregated protease-sensitive form (sPrP(Sc)). Although evidence suggests that sPrP(Sc) may play a role in prion pathogenesis, little is known about how it interacts with cells during prion infection. Here, we show that protease-sensitive abnormal PrP aggregates derived from patients with sporadic Creutzfeldt-Jakob disease are taken up and degraded by immortalized human astrocytes similarly to abnormal PrP aggregates that are resistant to proteases. Our data suggest that relative proteinase K resistance does not significantly influence the astrocyte's ability to degrade PrP(Sc). Furthermore, the cell does not appear to distinguish between sPrP(Sc) and protease-resistant PrP(Sc), suggesting that sPrP(Sc) could contribute to prion infection. Twit Text FOAVip Uptake and degradation of protease-sensitive and -resistant forms of abnormal human prion protein aggregates by human astrocytes ????Am J Pathol http://www.kidney.de/pget.php?&tw=1&pmid=25280631 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25280631 #FOAvip English Wikipedia <ref>{{Cite pmid|25280631 }}</ref> Uptake and degradation of protease-sensitive and -resistant forms of abnormal human prion protein aggregates by human astrocytes #MMPMID25280631 Choi YP ; Head MW ; Ironside JW ; Priola SA Am J Pathol 2014[Dec]; 184 (12 ): 3299-307 PMID25280631 show ga Sporadic Creutzfeldt-Jakob disease is the most common of the human prion diseases, a group of rare, transmissible, and fatal neurologic diseases associated with the accumulation of an abnormal form (PrP(Sc)) of the host prion protein. In sporadic Creutzfeldt-Jakob disease, disease-associated PrP(Sc) is present not only as an aggregated, protease-resistant form but also as an aggregated protease-sensitive form (sPrP(Sc)). Although evidence suggests that sPrP(Sc) may play a role in prion pathogenesis, little is known about how it interacts with cells during prion infection. Here, we show that protease-sensitive abnormal PrP aggregates derived from patients with sporadic Creutzfeldt-Jakob disease are taken up and degraded by immortalized human astrocytes similarly to abnormal PrP aggregates that are resistant to proteases. Our data suggest that relative proteinase K resistance does not significantly influence the astrocyte's ability to degrade PrP(Sc). Furthermore, the cell does not appear to distinguish between sPrP(Sc) and protease-resistant PrP(Sc), suggesting that sPrP(Sc) could contribute to prion infection. |Animals [MESH] |Astrocytes/cytology/*metabolism [MESH] |Brain/metabolism/*pathology [MESH] |Creutzfeldt-Jakob Syndrome/*metabolism [MESH] |Endopeptidase K/chemistry [MESH] |Epitopes/chemistry [MESH] |Fibroblasts/metabolism [MESH] |Humans [MESH] |Immunoprecipitation [MESH] |Mice [MESH] |Microscopy, Fluorescence [MESH] |Peptide Hydrolases/*chemistry [MESH] |Phosphotungstic Acid/chemistry [MESH] |PrPC Proteins/*metabolism [MESH] |PrPSc Proteins/metabolism [MESH] |Prion Diseases/metabolism [MESH]Uptake and degradation of protease-sensitive and -resistant forms of a(epmc).pdf DeepDyve Pubget Overpricing