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10.1016/j.gde.2014.08.010 http://scihub22266oqcxt.onion/10.1016/j.gde.2014.08.010 C4258459!4258459!25215415     free     free     free       Curr+Opin+Genet+Dev 2014 ; ä (ä): 68-74 Nephropedia Template TP {{tp|p=25215415|t=2014. Comparative studies of gene regulatory mechanisms |pdf=|usr=}}{{25215415}} gab.com Text Comparative studies of gene regulatory mechanisms JO: Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=25215415 #FOAvip It has become increasingly clear that changes in gene regulation have played an important role in adaptive evolution both between and within species. Over the past five years, comparative studies have moved beyond simple characterizations of differences in gene expression levels within and between species to studying variation in regulatory mechanisms. We still know relatively little about the precise chain of events that lead to most regulatory adaptations, but we have taken significant steps towards understanding the relative importance of changes in different mechanisms of gene regulatory evolution. In this review, we first discuss insights from comparative studies in model organisms, where the available experimental toolkit is extensive. We then focus on a few recent comparative studies in primates, where the limited feasibility of experimental manipulation dictates the approaches that can be used to study gene regulatory evolution. Twit Text FOAVip Comparative studies of gene regulatory mechanisms ????Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=25215415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25215415 #FOAvip English Wikipedia <ref>{{Cite pmid|25215415}}</ref> Comparative studies of gene regulatory mechanisms #MMPMID25215415 Pai AA; Gilad Y Curr Opin Genet Dev 2014[Dec]; ä (ä): 68-74 PMID25215415show ga It has become increasingly clear that changes in gene regulation have played an important role in adaptive evolution both between and within species. Over the past five years, comparative studies have moved beyond simple characterizations of differences in gene expression levels within and between species to studying variation in regulatory mechanisms. We still know relatively little about the precise chain of events that lead to most regulatory adaptations, but we have taken significant steps towards understanding the relative importance of changes in different mechanisms of gene regulatory evolution. In this review, we first discuss insights from comparative studies in model organisms, where the available experimental toolkit is extensive. We then focus on a few recent comparative studies in primates, where the limited feasibility of experimental manipulation dictates the approaches that can be used to study gene regulatory evolution. äComparative studies of gene regulatory mechanisms (epmc).pdf DeepDyve Pubget Overpricing