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10.4049/jimmunol.1401869 http://scihub22266oqcxt.onion/10.4049/jimmunol.1401869 C4258444!4258444!25385820     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25385820&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 193 (12): 6124-34 Nephropedia Template TP {{tp|p=25385820|t=2014. STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells |pdf=|usr=}}{{25385820}} gab.com Text STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25385820 #FOAvip Adaptive immune responses to antigens released by dying cells play a critical role in the development of autoimmunity, allograft rejection, and spontaneous as well as therapy-induced tumor rejection. Although cell death in these situations is considered sterile, various reports have implicated type I IFNs as drivers of the ensuing adaptive immune response to cell-associated antigens. However, the mechanisms that underpin this type I IFN production are poorly defined. Here we show that dendritic cells (DCs) can uptake and sense nuclear DNA-associated entities released by dying cells to induce type I IFN. Remarkably this molecular pathway requires STING but not TLR or NLR function and results in the activation of IRF3 in a TBK1-dependent manner. DCs are shown to depend on STING function in vivo to efficiently prime IFN-dependent CD8+ T cell responses to tumor antigens. Furthermore, loss of STING activity in DCs impairs the generation of follicular helper T (Tfh) and plasma cells as well as anti-nuclear antibodies in an inducible model of systemic lupus erythematosus (SLE). These findings suggest that the STING pathway could be manipulated to enable the rational design of immunotherapies that enhance or diminish anti-tumor and autoimmune responses, respectively. Twit Text FOAVip STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25385820 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25385820 #FOAvip English Wikipedia <ref>{{Cite pmid|25385820}}</ref> STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells #MMPMID25385820 Klarquist J; Hennies CM; Lehn MA; Reboulet RA; Feau S; Janssen EM J Immunol 2014[Dec]; 193 (12): 6124-34 PMID25385820show ga Adaptive immune responses to antigens released by dying cells play a critical role in the development of autoimmunity, allograft rejection, and spontaneous as well as therapy-induced tumor rejection. Although cell death in these situations is considered sterile, various reports have implicated type I IFNs as drivers of the ensuing adaptive immune response to cell-associated antigens. However, the mechanisms that underpin this type I IFN production are poorly defined. Here we show that dendritic cells (DCs) can uptake and sense nuclear DNA-associated entities released by dying cells to induce type I IFN. Remarkably this molecular pathway requires STING but not TLR or NLR function and results in the activation of IRF3 in a TBK1-dependent manner. DCs are shown to depend on STING function in vivo to efficiently prime IFN-dependent CD8+ T cell responses to tumor antigens. Furthermore, loss of STING activity in DCs impairs the generation of follicular helper T (Tfh) and plasma cells as well as anti-nuclear antibodies in an inducible model of systemic lupus erythematosus (SLE). These findings suggest that the STING pathway could be manipulated to enable the rational design of immunotherapies that enhance or diminish anti-tumor and autoimmune responses, respectively. äSTING-mediated DNA sensing promotes antitumor and autoimmune responses(epmc).pdf DeepDyve Pubget Overpricing