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10.1016/j.addr.2014.06.002

http://scihub22266oqcxt.onion/10.1016/j.addr.2014.06.002
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C4258430!4258430!24969477
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suck abstract from ncbi


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pmid24969477      Adv+Drug+Deliv+Rev 2014 ; ä (ä): 19-29
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  • Hydrogels to Model 3D in vitro Microenvironment of Tumor Vascularization #MMPMID24969477
  • Song HHG; Park KM; Gerecht S
  • Adv Drug Deliv Rev 2014[Dec]; ä (ä): 19-29 PMID24969477show ga
  • A growing number of failing clinical trials for cancer therapy is substantiating the need to upgrade the current practice in culturing tumor cells and modeling tumor angiogenesis in vitro. Many attempts have been made to engineer vasculature in vitro by utilizing hydrogels, but the application of these tools in simulating in vivo tumor angiogenesis is still very new. In this review, we explore current use of hydrogels and their design parameters to engineer vasculogenesis and angiogenesis and to evaluate the angiogenic capability of cancerous cells and tissues. When coupled with other technologies such as lithography and three-dimensional printing, one can even create an advanced microvessel model as microfluidic channels to more accurately capture the native angiogenesis process.
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