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10.1016/j.mib.2014.09.014 http://scihub22266oqcxt.onion/10.1016/j.mib.2014.09.014 C4258129!4258129!25305533     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Microbiol 2014 ; ä (ä): 15-21 Nephropedia Template TP {{tp|p=25305533|t=2014. New approaches to understanding the spatial organization of bacterial genomes |pdf=|usr=}}{{25305533}} gab.com Text New approaches to understanding the spatial organization of bacterial genomes JO: Curr Opin Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=25305533 #FOAvip In all organisms, chromosomal DNA must be compacted nearly three orders of magnitude to fit within the limited volume of a cell. However, chromosomes cannot be haphazardly packed, and instead must adopt structures compatible with numerous cellular processes, including DNA replication, chromosome segregation, recombination, and gene expression. Recent technical advances have dramatically enhanced our understanding of how chromosomes are organized in vivo and have begun to reveal the mechanisms and forces responsible. Here, we review the current arsenal of techniques used to query chromosome structure, focusing on (i) single-cell fluorescence microscopy approaches that directly examine chromosome structure and (ii) population-averaged biochemical methods that infer chromosome structure based on the interaction frequencies of different chromosomal loci. We describe the power of these techniques, highlighting the major advances they have produced while also discussing their limitations. Twit Text FOAVip New approaches to understanding the spatial organization of bacterial genomes ????Curr Opin Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=25305533 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25305533 #FOAvip English Wikipedia <ref>{{Cite pmid|25305533}}</ref> New approaches to understanding the spatial organization of bacterial genomes #MMPMID25305533 Le TBK; Laub MT Curr Opin Microbiol 2014[Dec]; ä (ä): 15-21 PMID25305533show ga In all organisms, chromosomal DNA must be compacted nearly three orders of magnitude to fit within the limited volume of a cell. However, chromosomes cannot be haphazardly packed, and instead must adopt structures compatible with numerous cellular processes, including DNA replication, chromosome segregation, recombination, and gene expression. Recent technical advances have dramatically enhanced our understanding of how chromosomes are organized in vivo and have begun to reveal the mechanisms and forces responsible. Here, we review the current arsenal of techniques used to query chromosome structure, focusing on (i) single-cell fluorescence microscopy approaches that directly examine chromosome structure and (ii) population-averaged biochemical methods that infer chromosome structure based on the interaction frequencies of different chromosomal loci. We describe the power of these techniques, highlighting the major advances they have produced while also discussing their limitations. äNew approaches to understanding the spatial organization of bacterial (epmc).pdf DeepDyve Pubget Overpricing