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10.1074/jbc.M114.611970

http://scihub22266oqcxt.onion/10.1074/jbc.M114.611970
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C4256366!4256366!25336634
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suck abstract from ncbi


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pmid25336634      J+Biol+Chem 2014 ; 289 (49): 34378-88
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  • Selenoprotein H Suppresses Cellular Senescence through Genome Maintenance and Redox Regulation* #MMPMID25336634
  • Wu RTY; Cao L; Chen BPC; Cheng WH
  • J Biol Chem 2014[Dec]; 289 (49): 34378-88 PMID25336634show ga
  • Background: Selenoprotein H (SelH), a proposed redox-responsive DNA-binding protein, is little-studied.Results: SelH shRNA cells display severe proliferation defects and accelerated senescence with abnormal responses to DNA damage and oxidative stress.Conclusion: SelH suppresses senescence and may have important roles in gatekeeping genomic integrity.Significance: Learning how SelH keeps senescence in check is crucial for advancing our understanding linking selenium and aging intervention.
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