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10.1074/jbc.M114.594721

http://scihub22266oqcxt.onion/10.1074/jbc.M114.594721
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C4256351!4256351!25331943
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suck abstract from ncbi


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pmid25331943      J+Biol+Chem 2014 ; 289 (49): 34189-204
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  • Nicotinamide Phosphoribosyltransferase Promotes Epithelial-to-Mesenchymal Transition as a Soluble Factor Independent of Its Enzymatic Activity* #MMPMID25331943
  • Soncini D; Caffa I; Zoppoli G; Cea M; Cagnetta A; Passalacqua M; Mastracci L; Boero S; Montecucco F; Sociali G; Lasiglič D; Damonte P; Grozio A; Mannino E; Poggi A; D'Agostino VG; Monacelli F; Provenzani A; Odetti P; Ballestrero A; Bruzzone S; Nencioni A
  • J Biol Chem 2014[Dec]; 289 (49): 34189-204 PMID25331943show ga
  • Background: Nicotinamide phosphoribosyltransferase (NAMPT) acts both as an enzyme in the production of the coenzyme NAD+ and as a secreted cytokine.Results: In breast cancer cells, NAMPT induces the epithelial-to-mesenchymal transition, a process that underlies metastasis, as a secreted protein independent of its enzymatic activity.Conclusion: Secreted NAMPT promotes epithelial-to-mesenchymal transition.Significance: Extracellular NAMPT neutralization may be of therapeutic value.
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