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10.1074/jbc.M114.604041

http://scihub22266oqcxt.onion/10.1074/jbc.M114.604041
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C4256341!4256341!25320093
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suck abstract from ncbi


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pmid25320093      J+Biol+Chem 2014 ; 289 (49): 34065-73
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  • Cellular Retinoic Acid-binding Protein 2 Inhibits Tumor Growth by Two Distinct Mechanisms* #MMPMID25320093
  • Vreeland AC; Levi L; Zhang W; Berry DC; Noy N
  • J Biol Chem 2014[Dec]; 289 (49): 34065-73 PMID25320093show ga
  • Background: CRABP2 delivers RA to its cognate nuclear receptor RAR and regulates gene expression by cooperating with HuR in stabilizing mRNAs.Results: In conjunction with HuR, CRABP2 regulates the expression of multiple cancer-related genes and suppresses tumor growth.Conclusion: The anticarcinogenic activities of CRABP2 are mediated by both HuR and RAR.Significance: The data demonstrate a novel mechanism through which CRABP2 inhibits tumorigenesis.
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