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10.1074/jbc.M114.609495

http://scihub22266oqcxt.onion/10.1074/jbc.M114.609495
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C4256334!4256334!25336651
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suck abstract from ncbi


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pmid25336651      J+Biol+Chem 2014 ; 289 (49): 33971-83
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  • Novel RNA-binding Protein P311 Binds Eukaryotic Translation Initiation Factor 3 Subunit b (eIF3b) to Promote Translation of Transforming Growth Factor ?1-3 (TGF-?1-3)* #MMPMID25336651
  • Yue MM; Lv K; Meredith SC; Martindale JL; Gorospe M; Schuger L
  • J Biol Chem 2014[Dec]; 289 (49): 33971-83 PMID25336651show ga
  • Background: P311 is a stimulator of TGF-?1-3 translation, but its mechanism of action is unknown.Results: P311 binds eIF3b and the 5?UTRs of TGF-?1-3 mRNAs. Thereby, P311 recruits TGF-?1-3 mRNAs to the translation machinery.Conclusion: P311 is an RNA-binding protein that binds to eIF3b to stimulate TGF-?1-3 translation.Significance: Our studies add a new level of complexity to TGF-? signaling regulation.
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