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10.1088/1478-3975/11/6/066007

http://scihub22266oqcxt.onion/10.1088/1478-3975/11/6/066007
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C4256082!4256082!25410646
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suck abstract from ncbi


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pmid25410646      Phys+Biol 2014 ; 11 (6): 066007
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  • Computational analysis of three-dimensional epithelial morphogenesis using vertex models #MMPMID25410646
  • Du X; Osterfield M; Shvartsman SY
  • Phys Biol 2014[Dec]; 11 (6): 066007 PMID25410646show ga
  • The folding of epithelial sheets, accompanied by cell shape changes and rearrangements, gives rise to three-dimensional structures during development. Recently, some aspects of epithelial morphogenesis have been modeled using vertex models, in which each cell is approximated by a polygon; however, these models have been largely confined to two dimensions. Here, we describe an adaptation of these models in which the classical two-dimensional vertex model is embedded in three dimensions. This modification allows for the construction of complex three-dimensional shapes from simple sheets of cells. We describe algorithmic, computational, and biophysical aspects of our model, with the view that it may be useful for formulating and testing hypotheses regarding the mechanical forces underlying a wide range of morphogenetic processes.
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