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10.1152/ajpcell.00270.2014 http://scihub22266oqcxt.onion/10.1152/ajpcell.00270.2014 C4254953!4254953 !25273880     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 261.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25273880 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Cell+Physiol 2014 ; 307 (11 ): C1058-67 Nephropedia Template TP {{tp|p=25273880 |t=2014. Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes |pdf=|usr=}}{{25273880 }} gab.com Text Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes JO: Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25273880 #FOAvip Dysfunction of macrophages (M?s) in diabetic wounds impairs the healing. M?s produce anti-inflammatory and pro-resolving neuroprotectin/protectin D1 (NPD1/PD1, 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid); however, little is known about endogenous NPD1 biosynthesis by M?s and the actions of NPD1 on diabetic M? functions in diabetic wound healing. We used an excisional skin wound model of diabetic mice, M? depletion, M?s isolated from diabetic mice, and mass spectrometry-based targeted lipidomics to study the time course progression of NPD1 levels in wounds, the roles of M?s in NPD1 biosynthesis, and NPD1 action on diabetic M? inflammatory activities. We also investigated the healing, innervation, chronic inflammation, and oxidative stress in diabetic wounds treated with NPD1 or NPD1-modulated M?s from diabetic mice. Injury induced endogenous NPD1 biosynthesis in wounds, but diabetes impeded NPD1 formation. NPD1 was mainly produced by M?s. NPD1 enhanced wound healing and innervation in diabetic mice and promoted M?s functions that accelerated these processes. The underlying mechanisms for these actions of NPD1 or NPD1-modulated M?s involved 1) attenuating M? inflammatory activities and chronic inflammation and oxidative stress after acute inflammation in diabetic wound, and 2) increasing M? production of IL10 and hepatocyte growth factor. Taken together, NPD1 appears to be a M?s-produced factor that accelerates diabetic wound healing and promotes M? pro-healing functions in diabetic wounds. Decreased NPD1 production in diabetic wound is associated with impaired healing. This study identifies a new molecular target that might be useful in development of more effective therapeutics based on NPD1 and syngeneic diabetic M?s for treatment of diabetic wounds. Twit Text FOAVip Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes ????Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=25273880 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25273880 #FOAvip English Wikipedia <ref>{{Cite pmid|25273880 }}</ref> Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes #MMPMID25273880 Hong S ; Tian H ; Lu Y ; Laborde JM ; Muhale FA ; Wang Q ; Alapure BV ; Serhan CN ; Bazan NG Am J Physiol Cell Physiol 2014[Dec]; 307 (11 ): C1058-67 PMID25273880 show ga Dysfunction of macrophages (M?s) in diabetic wounds impairs the healing. M?s produce anti-inflammatory and pro-resolving neuroprotectin/protectin D1 (NPD1/PD1, 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid); however, little is known about endogenous NPD1 biosynthesis by M?s and the actions of NPD1 on diabetic M? functions in diabetic wound healing. We used an excisional skin wound model of diabetic mice, M? depletion, M?s isolated from diabetic mice, and mass spectrometry-based targeted lipidomics to study the time course progression of NPD1 levels in wounds, the roles of M?s in NPD1 biosynthesis, and NPD1 action on diabetic M? inflammatory activities. We also investigated the healing, innervation, chronic inflammation, and oxidative stress in diabetic wounds treated with NPD1 or NPD1-modulated M?s from diabetic mice. Injury induced endogenous NPD1 biosynthesis in wounds, but diabetes impeded NPD1 formation. NPD1 was mainly produced by M?s. NPD1 enhanced wound healing and innervation in diabetic mice and promoted M?s functions that accelerated these processes. The underlying mechanisms for these actions of NPD1 or NPD1-modulated M?s involved 1) attenuating M? inflammatory activities and chronic inflammation and oxidative stress after acute inflammation in diabetic wound, and 2) increasing M? production of IL10 and hepatocyte growth factor. Taken together, NPD1 appears to be a M?s-produced factor that accelerates diabetic wound healing and promotes M? pro-healing functions in diabetic wounds. Decreased NPD1 production in diabetic wound is associated with impaired healing. This study identifies a new molecular target that might be useful in development of more effective therapeutics based on NPD1 and syngeneic diabetic M?s for treatment of diabetic wounds. |Animals [MESH] |Cells, Cultured [MESH] |Diabetes Complications/*metabolism [MESH] |Diabetes Mellitus, Type 2/*metabolism [MESH] |Docosahexaenoic Acids/*biosynthesis/chemistry/genetics/pharmacology [MESH] |Gene Expression Regulation [MESH] |Inflammation/metabolism [MESH] |Macrophages/*metabolism [MESH] |Mice [MESH] |Molecular Structure [MESH] |Oxidative Stress [MESH] |Skin/metabolism/pathology [MESH] |Wound Healing/*drug effects/physiology [MESH]Neuroprotectin/protectin D1: endogenous biosynthesis and actions on di(epmc).pdf DeepDyve Pubget Overpricing