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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Clin+Chest+Med 2014 ; 35 (4): 797-809 Nephropedia Template TP
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Endogenous and Exogenous Cell-Based Pathways for Recovery from ARDS #MMPMID25453426
Gotts JE; Matthay MA
Clin Chest Med 2014[Dec]; 35 (4): 797-809 PMID25453426show ga
Regenerative medicine has entered a rapid phase of discovery, and much has been learned in recent years about the lung?s response to injury. In this review, we first summarize the cellular and molecular mechanisms that damage the alveolar-capillary barrier, producing ARDS. We then turn our attention to the latest understanding of endogenous repair processes, highlighting the diversity of lung epithelial progenitor cell populations and their regulation in health and disease. Finally, we review the past, present and future of exogenous cell-based therapies for ARDS.