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10.1016/j.coi.2014.09.009

http://scihub22266oqcxt.onion/10.1016/j.coi.2014.09.009
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C4254640!4254640!25458996
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suck abstract from ncbi


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pmid25458996      Curr+Opin+Immunol 2014 ; ä (ä): 58-65
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  • I-L-C-2 it: type 2 immunity and group 2 innate lymphoid cells in homeostasis #MMPMID25458996
  • von Moltke J; Locksley RM
  • Curr Opin Immunol 2014[Dec]; ä (ä): 58-65 PMID25458996show ga
  • Innate type 2 immune cells are activated in response to helminths, allergens, and certain types of proteases and particulates. Recently, innate type 2 immune pathways have also been implicated in protective host responses to homeostatic perturbations, such as metabolic dysfunction, atherosclerosis, and tissue injury. In this context, innate type 2 cytokines stimulate local tissues, recruit eosinophils, and alternatively activate macrophages to restore homeostasis. As the major source of innate interleukin (IL)-5 and IL-13, group 2 innate lymphoid cells are positioned to initiate and maintain homeostatic type 2 responses. The absence of exogenous stimuli in these processes implicates endogenous pathways in the activation of type 2 immunity and suggests an alternative evolutionary trajectory for type 2 immunity, apart from its role in response to helminths and allergens.
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