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10.1016/j.ccell.2014.09.007 http://scihub22266oqcxt.onion/10.1016/j.ccell.2014.09.007 C4254577!4254577 !25446897     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25446897 &cmd=llinks): Failed to open stream: HTTP request failed! 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Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity |pdf=|usr=}}{{25446897 }} gab.com Text Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25446897 #FOAvip It is well understood that antigen-presenting cells (APCs) within tumors typically do not maintain cytotoxic T cell (CTL) function, despite engaging them. Across multiple mouse tumor models and human tumor biopsies, we have delineated the intratumoral dendritic cell (DC) populations as distinct from macrophage populations. Within these, CD103(+) DCs are extremely sparse and yet remarkably capable CTL stimulators. These are uniquely dependent on IRF8, Zbtb46, and Batf3 transcription factors and are generated by GM-CSF and FLT3L cytokines. Regressing tumors have higher proportions of these cells, T-cell-dependent immune clearance relies on them, and abundance of their transcripts in human tumors correlates with clinical outcome. This cell type presents opportunities for prognostic and therapeutic approaches across multiple cancer types. Twit Text FOAVip Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=25446897 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25446897 #FOAvip English Wikipedia <ref>{{Cite pmid|25446897 }}</ref> Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity #MMPMID25446897 Broz ML ; Binnewies M ; Boldajipour B ; Nelson AE ; Pollack JL ; Erle DJ ; Barczak A ; Rosenblum MD ; Daud A ; Barber DL ; Amigorena S ; Van't Veer LJ ; Sperling AI ; Wolf DM ; Krummel MF Cancer Cell 2014[Nov]; 26 (5 ): 638-52 PMID25446897 show ga It is well understood that antigen-presenting cells (APCs) within tumors typically do not maintain cytotoxic T cell (CTL) function, despite engaging them. Across multiple mouse tumor models and human tumor biopsies, we have delineated the intratumoral dendritic cell (DC) populations as distinct from macrophage populations. Within these, CD103(+) DCs are extremely sparse and yet remarkably capable CTL stimulators. These are uniquely dependent on IRF8, Zbtb46, and Batf3 transcription factors and are generated by GM-CSF and FLT3L cytokines. Regressing tumors have higher proportions of these cells, T-cell-dependent immune clearance relies on them, and abundance of their transcripts in human tumors correlates with clinical outcome. This cell type presents opportunities for prognostic and therapeutic approaches across multiple cancer types. |Animals [MESH] |Antigens, CD/metabolism [MESH] |Coculture Techniques [MESH] |Dendritic Cells/*immunology/metabolism [MESH] |Female [MESH] |Humans [MESH] |Immunotherapy, Adoptive [MESH] |Macrophages/metabolism [MESH] |Mammary Neoplasms, Experimental/*immunology/pathology/therapy [MESH] |Mice, Inbred C57BL [MESH] |Myeloid Cells/immunology/metabolism [MESH] |T-Lymphocytes/*immunology/metabolism [MESH] |Tumor Cells, Cultured [MESH]Dissecting the tumor myeloid compartment reveals rare activating ant(epmc).pdf DeepDyve Pubget Overpricing