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10.1016/j.devcel.2014.08.024 http://scihub22266oqcxt.onion/10.1016/j.devcel.2014.08.024 C4254419!4254419!25443298     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25443298.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Dev+Cell 2014 ; 31 (3): 319-31 Nephropedia Template TP {{tp|p=25443298|t=2014. B-LINK: A hemicentin, plakin and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes |pdf=|usr=}}{{25443298}} gab.com Text B-LINK: A hemicentin, plakin and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=25443298 #FOAvip Basement membrane (BM), a sheet-like form of extracellular matrix, surrounds most tissues. During organogenesis specific adhesions between adjoining tissues frequently occur, however their molecular basis is unclear. Using live-cell imaging and electron microscopy we identify an adhesion system that connects the uterine and gonadal tissues through their juxtaposed BMs at the site of anchor cell (AC) invasion in C. elegans. We find that the extracellular matrix component hemicentin (HIM-4), found between BMs, forms punctate accumulations under the AC and controls BM linkage to promote rapid invasion. Through targeted screening we identify the integrin-binding cytolinker plakin (VAB-10A) and integrin (INA-1/PAT-3) as key BM-BM linkage regulators: VAB-10A localizes to the AC-BM interface and tethers hemicentin to the AC while integrin promotes hemicentin punctae formation. Together, plakin, integrin and hemicentin are founding components of a cell-directed adhesion system, which we name a B-LINK (Basement membrane-LINKage), that connects adjacent tissues through adjoining BMs. Twit Text FOAVip B-LINK: A hemicentin, plakin and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=25443298 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25443298 #FOAvip English Wikipedia <ref>{{Cite pmid|25443298}}</ref> B-LINK: A hemicentin, plakin and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes #MMPMID25443298 Morrissey MA; Keeley DP; Hagedorn EJ; McClatchey STH; Chi Q; Hall DH; Sherwood DR Dev Cell 2014[Nov]; 31 (3): 319-31 PMID25443298show ga Basement membrane (BM), a sheet-like form of extracellular matrix, surrounds most tissues. During organogenesis specific adhesions between adjoining tissues frequently occur, however their molecular basis is unclear. Using live-cell imaging and electron microscopy we identify an adhesion system that connects the uterine and gonadal tissues through their juxtaposed BMs at the site of anchor cell (AC) invasion in C. elegans. We find that the extracellular matrix component hemicentin (HIM-4), found between BMs, forms punctate accumulations under the AC and controls BM linkage to promote rapid invasion. Through targeted screening we identify the integrin-binding cytolinker plakin (VAB-10A) and integrin (INA-1/PAT-3) as key BM-BM linkage regulators: VAB-10A localizes to the AC-BM interface and tethers hemicentin to the AC while integrin promotes hemicentin punctae formation. Together, plakin, integrin and hemicentin are founding components of a cell-directed adhesion system, which we name a B-LINK (Basement membrane-LINKage), that connects adjacent tissues through adjoining BMs. äB-LINK: A hemicentin, plakin and integrin-dependent adhesion system th(epmc).pdf DeepDyve Pubget Overpricing