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10.1016/j.exphem.2014.08.003 http://scihub22266oqcxt.onion/10.1016/j.exphem.2014.08.003 C4254082!4254082!25179751     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Hematol 2014 ; 42 (11): 976-986.e3 Nephropedia Template TP {{tp|p=25179751|t=2014. Activation of the vascular niche supports leukemic progression and resistance to chemotherapy |pdf=|usr=}}{{25179751}} gab.com Text Activation of the vascular niche supports leukemic progression and resistance to chemotherapy JO: Exp Hematol http://www.kidney.de/pget.php?&tw=1&pmid=25179751 #FOAvip Understanding the intricate cellular components of the bone marrow microenvironment can lead to the discovery of novel extrinsic factors that are responsible for the initiation and progression of leukemic disease. We have shown that endothelial cells (ECs) provide a fertile niche that allows for the propagation of primitive and aggressive leukemic clones. Activation of the ECs by VEGF-A provides cues that enable leukemic cells to proliferate at higher rates and also increases the adhesion of leukemia to ECs. VEGF-A activated ECs decrease the efficacy of chemotherapeutic agents to target leukemic cells. Inhibiting VEGF-dependent activation of ECs by blocking their signaling through VEGFR2 increases the susceptibility of leukemic cells to chemotherapy. Therefore, the development of drugs that target the activation state of the vascular niche could prove to be an effective adjuvant therapy in combination with chemotherapeutic agents. Twit Text FOAVip Activation of the vascular niche supports leukemic progression and resistance to chemotherapy ????Exp Hematol http://www.kidney.de/pget.php?&tw=1&pmid=25179751 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25179751 #FOAvip English Wikipedia <ref>{{Cite pmid|25179751}}</ref> Activation of the vascular niche supports leukemic progression and resistance to chemotherapy #MMPMID25179751 Poulos MG; Gars EJ; Gutkin MC; Kloss CC; Ginsberg M; Scandura JM; Rafii S; Butler JM Exp Hematol 2014[Nov]; 42 (11): 976-986.e3 PMID25179751show ga Understanding the intricate cellular components of the bone marrow microenvironment can lead to the discovery of novel extrinsic factors that are responsible for the initiation and progression of leukemic disease. We have shown that endothelial cells (ECs) provide a fertile niche that allows for the propagation of primitive and aggressive leukemic clones. Activation of the ECs by VEGF-A provides cues that enable leukemic cells to proliferate at higher rates and also increases the adhesion of leukemia to ECs. VEGF-A activated ECs decrease the efficacy of chemotherapeutic agents to target leukemic cells. Inhibiting VEGF-dependent activation of ECs by blocking their signaling through VEGFR2 increases the susceptibility of leukemic cells to chemotherapy. Therefore, the development of drugs that target the activation state of the vascular niche could prove to be an effective adjuvant therapy in combination with chemotherapeutic agents. äActivation of the vascular niche supports leukemic progression and res(epmc).pdf DeepDyve Pubget Overpricing