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10.1093/bioinformatics/btu581 http://scihub22266oqcxt.onion/10.1093/bioinformatics/btu581 C4253830!4253830!25172926     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Bioinformatics 2014 ; 30 (24): 3561-6 Nephropedia Template TP {{tp|p=25172926|t=2014. Human structural proteome-wide characterization of Cyclosporine A targets |pdf=|usr=}}{{25172926}} gab.com Text Human structural proteome-wide characterization of Cyclosporine A targets JO: Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=25172926 #FOAvip Motivation: Off-target interactions of a popular immunosuppressant Cyclosporine A (CSA) with several proteins besides its molecular target, cyclophilin A, are implicated in the activation of signaling pathways that lead to numerous side effects of this drug.Results: Using structural human proteome and a novel algorithm for inverse ligand binding prediction, ILbind, we determined a comprehensive set of 100+ putative partners of CSA. We empirically show that predictive quality of ILbind is better compared with other available predictors for this compound. We linked the putative target proteins, which include many new partners of CSA, with cellular functions, canonical pathways and toxicities that are typical for patients who take this drug. We used complementary approaches (molecular docking, molecular dynamics, surface plasmon resonance binding analysis and enzymatic assays) to validate and characterize three novel CSA targets: calpain 2, caspase 3 and p38 MAP kinase 14. The three targets are involved in the apoptotic pathways, are interconnected and are implicated in nephrotoxicity.Contact:lkurgan@ece.ualberta.caSupplementary information:Supplementary data are available at Bioinformatics online. Twit Text FOAVip Human structural proteome-wide characterization of Cyclosporine A targets ????Bioinformatics http://www.kidney.de/pget.php?&tw=1&pmid=25172926 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25172926 #FOAvip English Wikipedia <ref>{{Cite pmid|25172926}}</ref> Human structural proteome-wide characterization of Cyclosporine A targets #MMPMID25172926 Hu G; Wang K; Groenendyk J; Barakat K; Mizianty MJ; Ruan J; Michalak M; Kurgan L Bioinformatics 2014[Dec]; 30 (24): 3561-6 PMID25172926show ga Motivation: Off-target interactions of a popular immunosuppressant Cyclosporine A (CSA) with several proteins besides its molecular target, cyclophilin A, are implicated in the activation of signaling pathways that lead to numerous side effects of this drug.Results: Using structural human proteome and a novel algorithm for inverse ligand binding prediction, ILbind, we determined a comprehensive set of 100+ putative partners of CSA. We empirically show that predictive quality of ILbind is better compared with other available predictors for this compound. We linked the putative target proteins, which include many new partners of CSA, with cellular functions, canonical pathways and toxicities that are typical for patients who take this drug. We used complementary approaches (molecular docking, molecular dynamics, surface plasmon resonance binding analysis and enzymatic assays) to validate and characterize three novel CSA targets: calpain 2, caspase 3 and p38 MAP kinase 14. The three targets are involved in the apoptotic pathways, are interconnected and are implicated in nephrotoxicity.Contact:lkurgan@ece.ualberta.caSupplementary information:Supplementary data are available at Bioinformatics online. äHuman structural proteome-wide characterization of Cyclosporine A targ(epmc).pdf DeepDyve Pubget Overpricing