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10.1002/pro.2548 http://scihub22266oqcxt.onion/10.1002/pro.2548 C4253810!4253810 !25209176     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25209176 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Protein+Sci 2014 ; 23 (12 ): 1698-707 Nephropedia Template TP {{tp|p=25209176 |t=2014. Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF? reveal structural plasticity of antibody-antigen interactions |pdf=|usr=}}{{25209176 }} gab.com Text Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF reveal structural plasticity of antibody-antigen interactions JO: Protein Sci http://www.kidney.de/pget.php?&tw=1&pmid=25209176 #FOAvip Various important biological pathways are modulated by TGF? isoforms; as such they are potential targets for therapeutic intervention. Fresolimumab, also known as GC1008, is a pan-TGF? neutralizing antibody that has been tested clinically for several indications including an ongoing trial for focal segmental glomerulosclerosis. The structure of the antigen-binding fragment of fresolimumab (GC1008 Fab) in complex with TGF?3 has been reported previously, but the structural capacity of fresolimumab to accommodate tight interactions with TGF?1 and TGF?2 was insufficiently understood. We report the crystal structure of the single-chain variable fragment of fresolimumab (GC1008 scFv) in complex with target TGF?1 to a resolution of 3.00 Å and the crystal structure of GC1008 Fab in complex with TGF?2 to 2.83 Å. The structures provide further insight into the details of TGF? recognition by fresolimumab, give a clear indication of the determinants of fresolimumab pan-specificity and provide potential starting points for the development of isoform-specific antibodies using a fresolimumab scaffold. Twit Text FOAVip Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF reveal structural plasticity of antibody-antigen interactions ????Protein Sci http://www.kidney.de/pget.php?&tw=1&pmid=25209176 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25209176 #FOAvip English Wikipedia <ref>{{Cite pmid|25209176 }}</ref> Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF? reveal structural plasticity of antibody-antigen interactions #MMPMID25209176 Moulin A ; Mathieu M ; Lawrence C ; Bigelow R ; Levine M ; Hamel C ; Marquette JP ; Le Parc J ; Loux C ; Ferrari P ; Capdevila C ; Dumas J ; Dumas B ; Rak A ; Bird J ; Qiu H ; Pan CQ ; Edmunds T ; Wei RR Protein Sci 2014[Dec]; 23 (12 ): 1698-707 PMID25209176 show ga Various important biological pathways are modulated by TGF? isoforms; as such they are potential targets for therapeutic intervention. Fresolimumab, also known as GC1008, is a pan-TGF? neutralizing antibody that has been tested clinically for several indications including an ongoing trial for focal segmental glomerulosclerosis. The structure of the antigen-binding fragment of fresolimumab (GC1008 Fab) in complex with TGF?3 has been reported previously, but the structural capacity of fresolimumab to accommodate tight interactions with TGF?1 and TGF?2 was insufficiently understood. We report the crystal structure of the single-chain variable fragment of fresolimumab (GC1008 scFv) in complex with target TGF?1 to a resolution of 3.00 Å and the crystal structure of GC1008 Fab in complex with TGF?2 to 2.83 Å. The structures provide further insight into the details of TGF? recognition by fresolimumab, give a clear indication of the determinants of fresolimumab pan-specificity and provide potential starting points for the development of isoform-specific antibodies using a fresolimumab scaffold. |Antibodies, Monoclonal, Humanized [MESH] |Antibodies, Monoclonal/*chemistry/*immunology [MESH] |Antibodies, Neutralizing/chemistry/immunology [MESH] |Antibody Specificity/*immunology [MESH] |Antigen-Antibody Reactions/*immunology [MESH] |Crystallography, X-Ray [MESH] |Humans [MESH] |Immunoglobulin Fab Fragments/chemistry/immunology [MESH] |Models, Molecular [MESH] |Protein Conformation [MESH] |Protein Isoforms/chemistry/immunology [MESH] |Single-Chain Antibodies/chemistry/immunology [MESH]Structures of a pan-specific antagonist antibody complexed to differen(epmc).pdf DeepDyve Pubget Overpricing