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10.1158/0008-5472.CAN-14-1346 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-1346 C4253591!4253591!25297633     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Res 2014 ; 74 (23): 7024-36 Nephropedia Template TP {{tp|p=25297633|t=2014. Hedgehog signaling drives radioresistance and stroma-driven tumor repopulation in head and neck squamous cancers |pdf=|usr=}}{{25297633}} gab.com Text Hedgehog signaling drives radioresistance and stroma-driven tumor repopulation in head and neck squamous cancers JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25297633 #FOAvip Local control and overall survival in patients with advanced head and neck squamous cell cancer (HNSCC) remains dismal. Signaling through the Hedgehog (Hh) pathway is associated with epithelial-to-mesenchymal transition (EMT) and activation of the Hh effector transcription factor Gli1 is a poor prognostic factor in this disease setting. Here we report that increased GLI1 expression in the leading edge of HNSCC tumors is further increased by irradition where it contributes to therapy resistance. Hh pathway blockade with cyclopamine suppressed GLI1 activation and enhanced tumor sensitivity to radiotherapy. Further, radiotherapy-induced GLI1 expression was mediated in part by the mTOR/S6K1 pathway. Stroma exposed to radiotherapy promoted rapid tumor repopulation and this effect was suppressed by Hh inhibition. Our results demonstrate that GLI1 is upregulated at the tumor-stroma intersection in HNSCC is elevated by radiotherapy where it contributes to stromal-mediated resistance, and that Hh inhibitors offer a rational strategy to reverse this process to sensitize HNSCC to radiotherapy. Twit Text FOAVip Hedgehog signaling drives radioresistance and stroma-driven tumor repopulation in head and neck squamous cancers ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25297633 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25297633 #FOAvip English Wikipedia <ref>{{Cite pmid|25297633}}</ref> Hedgehog signaling drives radioresistance and stroma-driven tumor repopulation in head and neck squamous cancers #MMPMID25297633 Gan GN; Eagles J; Keysar SB; Wang G; Glogowska MJ; Altunbas C; Anderson RT; Le PN; Morton JJ; Frederick B; Raben D; Wang XJ; Jimeno A Cancer Res 2014[Dec]; 74 (23): 7024-36 PMID25297633show ga Local control and overall survival in patients with advanced head and neck squamous cell cancer (HNSCC) remains dismal. Signaling through the Hedgehog (Hh) pathway is associated with epithelial-to-mesenchymal transition (EMT) and activation of the Hh effector transcription factor Gli1 is a poor prognostic factor in this disease setting. Here we report that increased GLI1 expression in the leading edge of HNSCC tumors is further increased by irradition where it contributes to therapy resistance. Hh pathway blockade with cyclopamine suppressed GLI1 activation and enhanced tumor sensitivity to radiotherapy. Further, radiotherapy-induced GLI1 expression was mediated in part by the mTOR/S6K1 pathway. Stroma exposed to radiotherapy promoted rapid tumor repopulation and this effect was suppressed by Hh inhibition. Our results demonstrate that GLI1 is upregulated at the tumor-stroma intersection in HNSCC is elevated by radiotherapy where it contributes to stromal-mediated resistance, and that Hh inhibitors offer a rational strategy to reverse this process to sensitize HNSCC to radiotherapy. äHedgehog signaling drives radioresistance and stroma-driven tumor repo(epmc).pdf DeepDyve Pubget Overpricing