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10.1016/j.gde.2014.06.002

http://scihub22266oqcxt.onion/10.1016/j.gde.2014.06.002
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C4253552!4253552!25016437
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suck abstract from ncbi


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pmid25016437      Curr+Opin+Genet+Dev 2014 ; ä (ä): 53-8
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  • Chromatin: A Capacitor of Acetate for Integrated Regulation of Gene Expression and Cell Physiology #MMPMID25016437
  • Kurdistani SK
  • Curr Opin Genet Dev 2014[Jun]; ä (ä): 53-8 PMID25016437show ga
  • Cancer tissues with lower global levels of histone acetylation display significantly increased rate of tumor recurrence or cancer-related mortality. The function global regulation of histone acetylation serves for the cell or how lower levels of histone acetylation may contribute to a more aggressive cancer phenotype has been unclear. Chromatin and histone modifications are currently thought to regulate only DNA-based processes. However, recent findings have revealed a novel function for global histone acetylation in direct regulation of cellular physiology. I will discuss how chromatin, by regulating the cellular flux of acetate, may integrate control of cellular physiologic state with gene expression and help explain the observations in cancer tissues.
  • ä


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