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2014 ; 28
(4
): 601-13
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Prevention of human immunodeficiency virus and AIDS: postexposure prophylaxis
(including health care workers)
#MMPMID25287589
Beekmann SE
; Henderson DK
Infect Dis Clin North Am
2014[Dec]; 28
(4
): 601-13
PMID25287589
show ga
Postexposure prophylaxis (PEP), which is designed to prevent human
immunodeficiency virus (HIV) infection after an exposure, is one of several
strategies for HIV prevention. PEP was first used after occupational HIV
exposures in the late 1980s, with the Centers for Disease Control and Prevention
issuing the first set of guidelines that included considerations regarding the
use of antiretroviral agents for PEP after occupational HIV exposures in 1990.
Use of PEP has been extended to nonoccupational exposures, including after sexual
contact or injection-drug use. This article provides a rationale for PEP,
assessment of the need for PEP, and details of its implementation.