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10.1111/imm.12333 http://scihub22266oqcxt.onion/10.1111/imm.12333 C4253503!4253503 !24913005     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24913005 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunology 2014 ; 143 (4 ): 550-9 Nephropedia Template TP {{tp|p=24913005 |t=2014. Notch1 is an important mediator for enhancing of B-cell activation and antibody secretion by Notch ligand |pdf=|usr=}}{{24913005 }} gab.com Text Notch1 is an important mediator for enhancing of B-cell activation and antibody secretion by Notch ligand JO: Immunology http://www.kidney.de/pget.php?&tw=1&pmid=24913005 #FOAvip The roles of Notch1 and Notch2 in T-cell function have been well studied, but the functional roles of Notch in B cells have not been extensively investigated, except for Notch2 involvement in peripheral marginal zone B-cell differentiation. This study examined the roles of Notch1 in murine primary B cells. During B-cell activation by B-cell receptor ligation, Notch1 was up-regulated while Notch2 was not. In addition, Notch1 up-regulation itself did not contribute to the further activation of B cells, but the Notch ligand was important for Notch1-mediated further B-cell activation. Moreover, Notch1 deficiency significantly decreased B-cell activation and antibody secretion under the presence of Notch ligand. These data suggest that Notch1 is an important mediator for enhancing B-cell activation and antibody secretion by Notch ligand. Twit Text FOAVip Notch1 is an important mediator for enhancing of B-cell activation and antibody secretion by Notch ligand ????Immunology http://www.kidney.de/pget.php?&tw=1&pmid=24913005 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24913005 #FOAvip English Wikipedia <ref>{{Cite pmid|24913005 }}</ref> Notch1 is an important mediator for enhancing of B-cell activation and antibody secretion by Notch ligand #MMPMID24913005 Kang JA ; Kim WS ; Park SG Immunology 2014[Dec]; 143 (4 ): 550-9 PMID24913005 show ga The roles of Notch1 and Notch2 in T-cell function have been well studied, but the functional roles of Notch in B cells have not been extensively investigated, except for Notch2 involvement in peripheral marginal zone B-cell differentiation. This study examined the roles of Notch1 in murine primary B cells. During B-cell activation by B-cell receptor ligation, Notch1 was up-regulated while Notch2 was not. In addition, Notch1 up-regulation itself did not contribute to the further activation of B cells, but the Notch ligand was important for Notch1-mediated further B-cell activation. Moreover, Notch1 deficiency significantly decreased B-cell activation and antibody secretion under the presence of Notch ligand. These data suggest that Notch1 is an important mediator for enhancing B-cell activation and antibody secretion by Notch ligand. |Animals [MESH] |Antibody Formation/*genetics/*immunology [MESH] |B-Lymphocytes/cytology/*immunology/*metabolism [MESH] |Cell Differentiation/genetics [MESH] |Cell Line [MESH] |Gene Deletion [MESH] |Gene Expression [MESH] |Gene Knockout Techniques [MESH] |Humans [MESH] |Ligands [MESH] |Lymphocyte Activation/genetics/*immunology [MESH] |Mice [MESH] |Phenotype [MESH] |Protein Interaction Domains and Motifs [MESH] |Receptor, Notch1/agonists/chemistry/genetics/*metabolism [MESH]Notch1 is an important mediator for enhancing of B-cell activation and(epmc).pdf DeepDyve Pubget Overpricing