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2014 ; 15
(11
): 1128-38
Nephropedia Template TP
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English Wikipedia
Pleiotropic roles of Notch signaling in normal, malignant, and developmental
hematopoiesis in the human
#MMPMID25252682
Kushwah R
; Guezguez B
; Lee JB
; Hopkins CI
; Bhatia M
EMBO Rep
2014[Nov]; 15
(11
): 1128-38
PMID25252682
show ga
The Notch signaling pathway is evolutionarily conserved across species and plays
an important role in regulating cell differentiation, proliferation, and
survival. It has been implicated in several different hematopoietic processes
including early hematopoietic development as well as adult hematological
malignancies in humans. This review focuses on recent developments in
understanding the role of Notch signaling in the human hematopoietic system with
an emphasis on hematopoietic initiation from human pluripotent stem cells and
regulation within the bone marrow. Based on recent insights, we summarize
potential strategies for treatment of human hematological malignancies toward the
concept of targeting Notch signaling for fate regulation.