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10.1016/j.ygeno.2014.08.015 http://scihub22266oqcxt.onion/10.1016/j.ygeno.2014.08.015 C4252803!4252803!25181633     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genomics 2014 ; 104 (5): 314-23 Nephropedia Template TP {{tp|p=25181633|t=2014. 5-hydroxymethylcytosine: a stable or transient DNA modification?|pdf=|usr=}}{{25181633}} gab.com Text 5-hydroxymethylcytosine: a stable or transient DNA modification JO: Genomics http://www.kidney.de/pget.php?&tw=1&pmid=25181633 #FOAvip The DNA base 5-hydroxymethylcytosine (5hmC) is produced by enzymatic oxidation of 5-methylcytosine (5mC) by 5mC oxidases (the Tet proteins). Since 5hmC is recognized poorly by DNA methyltransferases, DNA methylation may be lost at 5hmC sites during DNA replication. In addition, 5hmC can be oxidized further by Tet proteins and converted to 5-formylcytosine and 5-carboxylcytosine, two bases that can be removed from DNA by base excision repair. The completed pathway represents a replication-independent DNA demethylation cycle. However, the DNA base 5hmC is also known to be rather stable and occurs at substantial levels, for example in the brain, suggesting that it represents an epigenetic mark by itself that may regulate chromatin structure and transcription. Focusing on a few well-studied tissues and developmental stages, we discuss the opposing views of 5hmC as a transient intermediate in DNA demethylation and as a modified DNA base with an instructive role. Twit Text FOAVip 5-hydroxymethylcytosine: a stable or transient DNA modification ????Genomics http://www.kidney.de/pget.php?&tw=1&pmid=25181633 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25181633 #FOAvip English Wikipedia <ref>{{Cite pmid|25181633}}</ref> 5-hydroxymethylcytosine: a stable or transient DNA modification? #MMPMID25181633 Hahn MA; Szabó PE; Pfeifer GP Genomics 2014[Nov]; 104 (5): 314-23 PMID25181633show ga The DNA base 5-hydroxymethylcytosine (5hmC) is produced by enzymatic oxidation of 5-methylcytosine (5mC) by 5mC oxidases (the Tet proteins). Since 5hmC is recognized poorly by DNA methyltransferases, DNA methylation may be lost at 5hmC sites during DNA replication. In addition, 5hmC can be oxidized further by Tet proteins and converted to 5-formylcytosine and 5-carboxylcytosine, two bases that can be removed from DNA by base excision repair. The completed pathway represents a replication-independent DNA demethylation cycle. However, the DNA base 5hmC is also known to be rather stable and occurs at substantial levels, for example in the brain, suggesting that it represents an epigenetic mark by itself that may regulate chromatin structure and transcription. Focusing on a few well-studied tissues and developmental stages, we discuss the opposing views of 5hmC as a transient intermediate in DNA demethylation and as a modified DNA base with an instructive role. ä5-hydroxymethylcytosine: a stable or transient DNA modification?(epmc).pdf DeepDyve Pubget Overpricing