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2014 ; 50
(ä): 14-9
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Oxytocin induces social communication by activating arginine-vasopressin V1a
receptors and not oxytocin receptors
#MMPMID25173438
Song Z
; McCann KE
; McNeill JK 4th
; Larkin TE 2nd
; Huhman KL
; Albers HE
Psychoneuroendocrinology
2014[Dec]; 50
(ä): 14-9
PMID25173438
show ga
Arginine-vasopressin (AVP) and oxytocin (OT) and their receptors are very similar
in structure. As a result, at least some of the effects of these peptides may be
the result of crosstalk between their canonical receptors. The present study
investigated this hypothesis by determining whether the induction of flank
marking, a form of social communication in Syrian hamsters, by OT is mediated by
the OT receptor or the AVP V1a receptor. Intracerebroventricular (ICV) injections
of OT or AVP induced flank marking in a dose-dependent manner although the
effects of AVP were approximately 100 times greater than those of OT. Injections
of highly selective V1a receptor agonists but not OT receptor agonists induced
flank marking, and V1a receptor antagonists but not OT receptor antagonists
significantly inhibited the ability of OT to induce flank marking. Lastly,
injection of alpha-melanocyte-stimulating hormone (?-MSH), a peptide that
stimulates OT but not AVP release, significantly increased odor-induced flank
marking, and these effects were blocked by a V1a receptor antagonist. These data
demonstrate that OT induces flank marking by activating AVP V1a and not OT
receptors, suggesting that the V1a receptor should be considered to be an OT
receptor as well as an AVP receptor.