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10.1523/JNEUROSCI.3020-14.2014 http://scihub22266oqcxt.onion/10.1523/JNEUROSCI.3020-14.2014 C4252540!4252540!25471560     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurosci 2014 ; 34 (49): 16180-93 Nephropedia Template TP {{tp|p=25471560|t=2014. Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury |pdf=|usr=}}{{25471560}} gab.com Text Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury JO: J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25471560 #FOAvip Traumatic brain injury (TBI) is an established risk factor for the early development of dementia, including Alzheimer's disease, and the post-traumatic brain frequently exhibits neurofibrillary tangles comprised of aggregates of the protein tau. We have recently defined a brain-wide network of paravascular channels, termed the ?glymphatic? pathway, along which CSF moves into and through the brain parenchyma, facilitating the clearance of interstitial solutes, including amyloid-?, from the brain. Here we demonstrate in mice that extracellular tau is cleared from the brain along these paravascular pathways. After TBI, glymphatic pathway function was reduced by ?60%, with this impairment persisting for at least 1 month post injury. Genetic knock-out of the gene encoding the astroglial water channel aquaporin-4, which is importantly involved in paravascular interstitial solute clearance, exacerbated glymphatic pathway dysfunction after TBI and promoted the development of neurofibrillary pathology and neurodegeneration in the post-traumatic brain. These findings suggest that chronic impairment of glymphatic pathway function after TBI may be a key factor that renders the post-traumatic brain vulnerable to tau aggregation and the onset of neurodegeneration. Twit Text FOAVip Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury ????J Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25471560 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25471560 #FOAvip English Wikipedia <ref>{{Cite pmid|25471560}}</ref> Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury #MMPMID25471560 Iliff JJ; Chen MJ; Plog BA; Zeppenfeld DM; Soltero M; Yang L; Singh I; Deane R; Nedergaard M J Neurosci 2014[Dec]; 34 (49): 16180-93 PMID25471560show ga Traumatic brain injury (TBI) is an established risk factor for the early development of dementia, including Alzheimer's disease, and the post-traumatic brain frequently exhibits neurofibrillary tangles comprised of aggregates of the protein tau. We have recently defined a brain-wide network of paravascular channels, termed the ?glymphatic? pathway, along which CSF moves into and through the brain parenchyma, facilitating the clearance of interstitial solutes, including amyloid-?, from the brain. Here we demonstrate in mice that extracellular tau is cleared from the brain along these paravascular pathways. After TBI, glymphatic pathway function was reduced by ?60%, with this impairment persisting for at least 1 month post injury. Genetic knock-out of the gene encoding the astroglial water channel aquaporin-4, which is importantly involved in paravascular interstitial solute clearance, exacerbated glymphatic pathway dysfunction after TBI and promoted the development of neurofibrillary pathology and neurodegeneration in the post-traumatic brain. These findings suggest that chronic impairment of glymphatic pathway function after TBI may be a key factor that renders the post-traumatic brain vulnerable to tau aggregation and the onset of neurodegeneration. äImpairment of Glymphatic Pathway Function Promotes Tau Pathology after(epmc).pdf DeepDyve Pubget Overpricing