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10.1016/j.cgh.2014.06.019 http://scihub22266oqcxt.onion/10.1016/j.cgh.2014.06.019 C4252508!4252508!24993367     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Clin+Gastroenterol+Hepatol 2014 ; 12 (12): 2015-22 Nephropedia Template TP {{tp|p=24993367|t=2014. Markers of Eosinophilic Inflammation for Diagnosis of Eosinophilic Esophagitis and Proton PumpInhibitor-Responsive Esophageal Eosinophilia: a Prospective Study |pdf=|usr=}}{{24993367}} gab.com Text Markers of Eosinophilic Inflammation for Diagnosis of Eosinophilic Esophagitis and Proton PumpInhibitor-Responsive Esophageal Eosinophilia: a Prospective Study JO: Clin Gastroenterol Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=24993367 #FOAvip Background & Aims: Distinguishing between eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), and proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is challenging. We assessed whether immunohistochemical analysis of esophageal tissues for major basic protein (MBP), eotaxin3, and tryptase can be used in diagnosis of EoE and to differentiate EoE from PPI-REE. Methods: We conducted a prospective study of 196 consecutive adults who underwent outpatient endoscopy at the University of North Carolina from 2009 through 2012. Incident cases of EoE were diagnosed per consensus guidelines. Patients with gastroesophageal reflux disease or dysphagia served as controls. PPI-REE was defined as a symptomatic and histologic response to a PPI. Immunohistochemistry was performed to quantify MBP, eotaxin3, and tryptase. The maximum density of epithelial staining was determined for each assay; levels were compared between EoE and control, and then EoE and PPI-REE groups, and receiver operator characteristic (ROC) curves were constructed. Results: Esophageal tissues from patients with EoE (n=50) had a median 951 MBP-positive cells/mm2 whereas those from controls (n=123) had a median 2 MBP-positive cells/mm2 (P<.001). Samples from patients with EoE had a median 155 eotaxin3-positive cells/mm2 and those from controls (n=123) had 18 MBP-positive cells/mm2 (P<.001). Samples from patients with EoE had a median 249 tryptase-positive cells/mm2 and those from controls (n=123) had 11 tryptase-positive cells/mm2 (P<.001). Levels of MBP, eotaxin3, tryptase, and the combination of all 3 identified patients with EoE with area under the ROC curve values of 0.99, 0.94, 0.99, and 1.00. Analyses of only samples with eosinophil counts of 10?100 eos/hpf produced similar results. No marker distinguished EoE from PPI-REE. Esophageal tissues from patients with PPI-REE (n=23) had 987 MBP-positive cells/mm2 (P=.18, compared with controls), 160 eotaxin3-positive cells/mm2 (P=.33), and 243 tryptase-positive cells/mm2 (P=.28). Conclusions: Esophageal tissues from patients with EoE have substantially higher levels of MBP, eotaxin3, and tryptase than controls, based in immunohistochemical analysis. Assays for the 3 markers identify patients with EoE 100% accuracy, but cannot distinguish EoE from PPI-REE. Twit Text FOAVip Markers of Eosinophilic Inflammation for Diagnosis of Eosinophilic Esophagitis and Proton PumpInhibitor-Responsive Esophageal Eosinophilia: a Prospective Study ????Clin Gastroenterol Hepatol http://www.kidney.de/pget.php?&tw=1&pmid=24993367 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24993367 #FOAvip English Wikipedia <ref>{{Cite pmid|24993367}}</ref> Markers of Eosinophilic Inflammation for Diagnosis of Eosinophilic Esophagitis and Proton PumpInhibitor-Responsive Esophageal Eosinophilia: a Prospective Study #MMPMID24993367 Dellon ES; Speck O; Woodward K; Covey S; Rusin S; Gebhart JH; Chen X; Woosley JT; Shaheen NJ Clin Gastroenterol Hepatol 2014[Dec]; 12 (12): 2015-22 PMID24993367show ga Background & Aims: Distinguishing between eosinophilic esophagitis (EoE), gastroesophageal reflux disease (GERD), and proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is challenging. We assessed whether immunohistochemical analysis of esophageal tissues for major basic protein (MBP), eotaxin3, and tryptase can be used in diagnosis of EoE and to differentiate EoE from PPI-REE. Methods: We conducted a prospective study of 196 consecutive adults who underwent outpatient endoscopy at the University of North Carolina from 2009 through 2012. Incident cases of EoE were diagnosed per consensus guidelines. Patients with gastroesophageal reflux disease or dysphagia served as controls. PPI-REE was defined as a symptomatic and histologic response to a PPI. Immunohistochemistry was performed to quantify MBP, eotaxin3, and tryptase. The maximum density of epithelial staining was determined for each assay; levels were compared between EoE and control, and then EoE and PPI-REE groups, and receiver operator characteristic (ROC) curves were constructed. Results: Esophageal tissues from patients with EoE (n=50) had a median 951 MBP-positive cells/mm2 whereas those from controls (n=123) had a median 2 MBP-positive cells/mm2 (P<.001). Samples from patients with EoE had a median 155 eotaxin3-positive cells/mm2 and those from controls (n=123) had 18 MBP-positive cells/mm2 (P<.001). Samples from patients with EoE had a median 249 tryptase-positive cells/mm2 and those from controls (n=123) had 11 tryptase-positive cells/mm2 (P<.001). Levels of MBP, eotaxin3, tryptase, and the combination of all 3 identified patients with EoE with area under the ROC curve values of 0.99, 0.94, 0.99, and 1.00. Analyses of only samples with eosinophil counts of 10?100 eos/hpf produced similar results. No marker distinguished EoE from PPI-REE. Esophageal tissues from patients with PPI-REE (n=23) had 987 MBP-positive cells/mm2 (P=.18, compared with controls), 160 eotaxin3-positive cells/mm2 (P=.33), and 243 tryptase-positive cells/mm2 (P=.28). Conclusions: Esophageal tissues from patients with EoE have substantially higher levels of MBP, eotaxin3, and tryptase than controls, based in immunohistochemical analysis. Assays for the 3 markers identify patients with EoE 100% accuracy, but cannot distinguish EoE from PPI-REE. äMarkers of Eosinophilic Inflammation for Diagnosis of Eosinophilic Eso(epmc).pdf DeepDyve Pubget Overpricing