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10.1016/j.conb.2014.05.003

http://scihub22266oqcxt.onion/10.1016/j.conb.2014.05.003
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C4252488!4252488!24907657
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suck abstract from ncbi

pmid24907657      Curr+Opin+Neurobiol 2014 ; ä (ä): 48-56
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  • Neuromodulation of Neurons and Synapses #MMPMID24907657
  • Nadim F; Bucher D
  • Curr Opin Neurobiol 2014[Dec]; ä (ä): 48-56 PMID24907657show ga
  • Neuromodulation underlies the flexibility of neural circuit operation and behavior. Individual neuromodulators can have divergent actions in a neuron by targeting multiple physiological mechanisms. Conversely, multiple neuromodulators may have convergent actions through overlapping targets. Additionally, the divergent and convergent neuromodulator actions can be unambiguously synergistic or antagonistic. Neuromodulation often entails balanced adjustment of nonlinear membrane and synaptic properties by targeting ion channel and synaptic dynamics rather than just excitability or synaptic strength. In addition, neuromodulators can exert effects at multiple timescales, from short-term adjustments of neuron and synapse function to persistent long-term regulation. This short review summarizes some highlights of the diverse actions of neuromodulators on ion channel and synaptic properties.
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