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10.1016/j.molonc.2014.06.006 http://scihub22266oqcxt.onion/10.1016/j.molonc.2014.06.006 C4252481!4252481 !24994678     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24994678 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Oncol 2014 ; 8 (8 ): 1532-47 Nephropedia Template TP {{tp|p=24994678 |t=2014. HER2 mediated de novo production of TGF? leads to SNAIL driven epithelial-to-mesenchymal transition and metastasis of breast cancer |pdf=|usr=}}{{24994678 }} gab.com Text HER2 mediated de novo production of TGF leads to SNAIL driven epithelial-to-mesenchymal transition and metastasis of breast cancer JO: Mol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=24994678 #FOAvip HER2 is an important determinant of poor prognosis in breast cancer patients. Studies indicate that HER2 positive tumors are mostly resistant to therapy and have high metastatic potential however, the underlying mechanisms remain unknown. In this study, MDA-MB-231 and MCF-7 breast cancer cells with their HER2 overexpressing syngeneic variants were used to delineate the role of HER2 in EMT and metastasis. Our results demonstrated that HER2 overexpression increased the invasive potential of cells. Our results also showed that HER2 overexpression lead to the production of TGF? resulting in the activation of TGF?/SMAD signaling. Furthermore, activation of SNAIL, SLUG and ZEB-1, the transcriptional repressors of E-cadherin and increased mesenchymal characteristics were observed in high HER2 cells. Interestingly, EMT by HER2 was mediated through TGF?. Intravenous injection of high HER2 MDA-MB-231 (HH) cells in athymic nude mice showed early and substantial metastasis as compared to the parent cells establishing the direct role of HER2 in metastasis. Our results showed that inhibition of HER2 mediated EMT by cucurbitacin B a triterpenoid, resulted in the suppression of brain metastasis of breast cancer cells. Taken together, our results identify a novel mechanism of HER2 in promoting breast cancer metastasis through de novo synthesis of TGF? leading to EMT, an initial and essential step of metastasis. Twit Text FOAVip HER2 mediated de novo production of TGF leads to SNAIL driven epithelial-to-mesenchymal transition and metastasis of breast cancer ????Mol Oncol http://www.kidney.de/pget.php?&tw=1&pmid=24994678 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24994678 #FOAvip English Wikipedia <ref>{{Cite pmid|24994678 }}</ref> HER2 mediated de novo production of TGF? leads to SNAIL driven epithelial-to-mesenchymal transition and metastasis of breast cancer #MMPMID24994678 Gupta P ; Srivastava SK Mol Oncol 2014[Dec]; 8 (8 ): 1532-47 PMID24994678 show ga HER2 is an important determinant of poor prognosis in breast cancer patients. Studies indicate that HER2 positive tumors are mostly resistant to therapy and have high metastatic potential however, the underlying mechanisms remain unknown. In this study, MDA-MB-231 and MCF-7 breast cancer cells with their HER2 overexpressing syngeneic variants were used to delineate the role of HER2 in EMT and metastasis. Our results demonstrated that HER2 overexpression increased the invasive potential of cells. Our results also showed that HER2 overexpression lead to the production of TGF? resulting in the activation of TGF?/SMAD signaling. Furthermore, activation of SNAIL, SLUG and ZEB-1, the transcriptional repressors of E-cadherin and increased mesenchymal characteristics were observed in high HER2 cells. Interestingly, EMT by HER2 was mediated through TGF?. Intravenous injection of high HER2 MDA-MB-231 (HH) cells in athymic nude mice showed early and substantial metastasis as compared to the parent cells establishing the direct role of HER2 in metastasis. Our results showed that inhibition of HER2 mediated EMT by cucurbitacin B a triterpenoid, resulted in the suppression of brain metastasis of breast cancer cells. Taken together, our results identify a novel mechanism of HER2 in promoting breast cancer metastasis through de novo synthesis of TGF? leading to EMT, an initial and essential step of metastasis. |Blotting, Western [MESH] |Breast Neoplasms/genetics/*metabolism [MESH] |Cell Line, Tumor [MESH] |Chromatin Immunoprecipitation [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Epithelial-Mesenchymal Transition/genetics/physiology [MESH] |Female [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Neoplasm Metastasis/*genetics [MESH] |Reverse Transcriptase Polymerase Chain Reaction [MESH] |Snail Family Transcription Factors [MESH] |Transcription Factors/genetics/*metabolism [MESH]HER2 mediated de novo production of TGF? leads to SNAIL driven epith(epmc).pdf DeepDyve Pubget Overpricing