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10.1158/0008-5472.CAN-14-2043 http://scihub22266oqcxt.onion/10.1158/0008-5472.CAN-14-2043 C4252249!4252249 !25304264     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25304264 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Res 2014 ; 74 (23 ): 7069-78 Nephropedia Template TP {{tp|p=25304264 |t=2014. Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor |pdf=|usr=}}{{25304264 }} gab.com Text Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor JO: Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25304264 #FOAvip Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we investigated whether these drugs might subvert host immunity by activating PAF-R. Here, we show that PAF-R agonists are produced in melanoma cells by chemotherapy that is administered in vitro, in vivo, or in human subjects. Structural characterization of the PAF-R agonists induced revealed multiple oxidized glycerophosphocholines that are generated nonenzymatically. In a murine model of melanoma, chemotherapeutic administration could augment tumor growth by a PAF-R-dependent process that could be blocked by treatment with antioxidants or COX-2 inhibitors or by depletion of regulatory T cells. Our findings reveal how PAF-R agonists induced by chemotherapy treatment can promote treatment failure. Furthermore, they offer new insights into how to improve the efficacy of chemotherapy by blocking its heretofore unknown impact on PAF-R activation. Twit Text FOAVip Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor ????Cancer Res http://www.kidney.de/pget.php?&tw=1&pmid=25304264 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25304264 #FOAvip English Wikipedia <ref>{{Cite pmid|25304264 }}</ref> Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor #MMPMID25304264 Sahu RP ; Ocana JA ; Harrison KA ; Ferracini M ; Touloukian CE ; Al-Hassani M ; Sun L ; Loesch M ; Murphy RC ; Althouse SK ; Perkins SM ; Speicher PJ ; Tyler DS ; Konger RL ; Travers JB Cancer Res 2014[Dec]; 74 (23 ): 7069-78 PMID25304264 show ga Oxidative stress suppresses host immunity by generating oxidized lipid agonists of the platelet-activating factor receptor (PAF-R). Because many classical chemotherapeutic drugs induce reactive oxygen species (ROS), we investigated whether these drugs might subvert host immunity by activating PAF-R. Here, we show that PAF-R agonists are produced in melanoma cells by chemotherapy that is administered in vitro, in vivo, or in human subjects. Structural characterization of the PAF-R agonists induced revealed multiple oxidized glycerophosphocholines that are generated nonenzymatically. In a murine model of melanoma, chemotherapeutic administration could augment tumor growth by a PAF-R-dependent process that could be blocked by treatment with antioxidants or COX-2 inhibitors or by depletion of regulatory T cells. Our findings reveal how PAF-R agonists induced by chemotherapy treatment can promote treatment failure. Furthermore, they offer new insights into how to improve the efficacy of chemotherapy by blocking its heretofore unknown impact on PAF-R activation. |Animals [MESH] |Antineoplastic Agents/*immunology/*pharmacology [MESH] |Antioxidants/pharmacology [MESH] |Cell Line, Tumor [MESH] |Cyclooxygenase 2 Inhibitors/immunology/pharmacology [MESH] |Female [MESH] |Glycerylphosphorylcholine/immunology/metabolism [MESH] |Humans [MESH] |Melanoma, Experimental/*drug therapy/*immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Oxidative Stress/drug effects/immunology [MESH] |Platelet Activating Factor/*agonists/immunology/metabolism [MESH] |Platelet Membrane Glycoproteins/immunology/metabolism [MESH] |Reactive Oxygen Species/immunology/metabolism [MESH] |Receptors, G-Protein-Coupled/immunology/metabolism [MESH] |Signal Transduction/drug effects/immunology [MESH]Chemotherapeutic agents subvert tumor immunity by generating agonists (epmc).pdf DeepDyve Pubget Overpricing