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10.1038/ni.2960 http://scihub22266oqcxt.onion/10.1038/ni.2960 C4251968!4251968!25129370     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2014 ; 15 (10): 947-56 Nephropedia Template TP {{tp|p=25129370|t=2014. A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells |pdf=|usr=}}{{25129370}} gab.com Text A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25129370 #FOAvip The transcription factor ThPOK promotes CD4+ T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4+ T lineage integrity and couples effector differentiation to environmental cues after antigenic stimulation. ThPOK preserved the integrity and amplitude of effector responses, and was required for proper TH1 and TH2 differentiation in vivo by restraining the expression and function of the transcriptional regulator of cytotoxic T cell differentiation, Runx3. The transcription factor LRF contributed in a redundant manner with ThPOK to prevent the trans-differentiation of mature CD4+ T cells into CD8+ T cells. As such, the ThPOK-LRF transcriptional module was essential for CD4+ T cell integrity and responses. Twit Text FOAVip A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25129370 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25129370 #FOAvip English Wikipedia <ref>{{Cite pmid|25129370}}</ref> A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells #MMPMID25129370 Vacchio MS; Wang L; Bouladoux N; Carpenter AC; Xiong Y; Williams LC; Wohlfert E; Song KD; Belkaid Y; Love PE; Bosselut R Nat Immunol 2014[Oct]; 15 (10): 947-56 PMID25129370show ga The transcription factor ThPOK promotes CD4+ T cell differentiation in the thymus. Here, using a mouse strain that allows post-thymic gene deletion, we show that ThPOK maintains CD4+ T lineage integrity and couples effector differentiation to environmental cues after antigenic stimulation. ThPOK preserved the integrity and amplitude of effector responses, and was required for proper TH1 and TH2 differentiation in vivo by restraining the expression and function of the transcriptional regulator of cytotoxic T cell differentiation, Runx3. The transcription factor LRF contributed in a redundant manner with ThPOK to prevent the trans-differentiation of mature CD4+ T cells into CD8+ T cells. As such, the ThPOK-LRF transcriptional module was essential for CD4+ T cell integrity and responses. äA ThPOK-LRF transcriptional node maintains the integrity and effector (epmc).pdf DeepDyve Pubget Overpricing